A Natural Fungal Gene Drive Enacts Killing via DNA Disruption.
DNA
filamentous fungi
fungi
gene drives
mechanism
nucleases
spore killer
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
28 02 2023
28 02 2023
Historique:
pubmed:
21
12
2022
medline:
3
3
2023
entrez:
20
12
2022
Statut:
ppublish
Résumé
Fungal spore killers are a class of selfish genetic elements that positively bias their own inheritance by killing non-inheriting gametes following meiosis. As killing takes place specifically within the developing fungal ascus, a tissue which is experimentally difficult to isolate, our understanding of the mechanisms underlying spore killers are limited. In particular, how these loci kill other spores within the fungal ascus is largely unknown. Here, we overcome these experimental barriers by developing model systems in 2 evolutionary distant organisms, Escherichia coli (bacterium) and Saccharomyces cerevisiae (yeast), similar to previous approaches taken to examine the
Identifiants
pubmed: 36537809
doi: 10.1128/mbio.03173-22
pmc: PMC9972908
doi:
Substances chimiques
DNA
9007-49-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0317322Références
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