Increased PHOSPHO1 and alkaline phosphatase expression during the anabolic bone response to intermittent parathyroid hormone delivery.
PHOSPHO1
SMPD3
TNAP
bone mineralisation
intermittent PTH
phosphatase
Journal
Cell biochemistry and function
ISSN: 1099-0844
Titre abrégé: Cell Biochem Funct
Pays: England
ID NLM: 8305874
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
revised:
02
12
2022
received:
19
07
2022
accepted:
09
12
2022
pubmed:
22
12
2022
medline:
15
3
2023
entrez:
21
12
2022
Statut:
ppublish
Résumé
The administration of intermittent parathyroid hormone (iPTH) is anabolic to the skeleton. Recent studies with cultured osteoblasts have revealed that the expression of PHOSPHO1, a bone-specific phosphatase essential for the initiation of mineralisation, is regulated by PTH. Therefore, this study sought to determine whether the bone anabolic response to iPTH involves modulation of expression of Phospho1 and of other enzymes critical for bone matrix mineralisation. To mimic iPTH treatment, primary murine osteoblasts were challenged with 50 nM PTH for 6 h in every 48 h period for 8 days (4 cycles), 14 days (7 cycles) and 20 days (10 cycles) in total. The expression of both Phospho1 and Smpd3 was almost completely inhibited after 4 cycles, whereas 10 cycles were required to stimulate a similar response in Alpl expression. To explore the in vivo role of PHOSPHO1 in PTH-mediated osteogenesis, the effects of 14- and 28-day iPTH (80 µg/kg/day) administration was assessed in male wild-type (WT) and Phospho1
Substances chimiques
Parathyroid Hormone
0
Alkaline Phosphatase
EC 3.1.3.1
Smpd3 protein, mouse
EC 3.1.4.12
Sphingomyelin Phosphodiesterase
EC 3.1.4.12
PHOSPHO1 protein, mouse
EC 3.1.3.-
Phosphoric Monoester Hydrolases
EC 3.1.3.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
189-201Subventions
Organisme : BB/J004316/1
Organisme : BB/J01446X/1
Organisme : Biotechnology and Biological Sciences Research Council
Pays : United Kingdom
Informations de copyright
© 2022 The Authors. Cell Biochemistry and Function published by John Wiley & Sons Ltd.
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