Modeling the Interplay between HDV and HBV in Chronic HDV/HBV Patients.

analytical solution anti-HDV treatment hepatitis B virus hepatitis delta virus

Journal

Mathematics (Basel, Switzerland)
ISSN: 2227-7390
Titre abrégé: Mathematics (Basel)
Pays: Switzerland
ID NLM: 101766564

Informations de publication

Date de publication:
02 Oct 2022
Historique:
entrez: 21 12 2022
pubmed: 22 12 2022
medline: 22 12 2022
Statut: ppublish

Résumé

Hepatitis D virus is an infectious subviral agent that can only propagate in people infected with hepatitis B virus. In this study, we modified and further developed a recent model for early hepatitis D virus and hepatitis B virus kinetics to better reproduce hepatitis D virus and hepatitis B virus kinetics measured in infected patients during anti-hepatitis D virus treatment. The analytical solutions were provided to highlight the new features of the modified model. The improved model offered significantly better prospects for modeling hepatitis D virus and hepatitis B virus interactions.

Identifiants

DOI: 10.3390/math10203917 PMID: 36540372 PMC: PMC9762680
pubmed: 36540372
doi: 10.3390/math10203917
pmc: PMC9762680
mid: NIHMS1844868
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI144112
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI146917
Pays : United States

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Auteurs

Adequate Mhlanga (A)

The Program for Experimental and Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 84101, USA.

Rami Zakh (R)

Department of Computer Science, Ben-Gurion University, Beer-Sheva 84105, Israel.
Department of Software Engineering, Sami Shamoon College of Engineering, Beer-Sheva 84108, Israel.

Alexander Churkin (A)

Department of Software Engineering, Sami Shamoon College of Engineering, Beer-Sheva 84108, Israel.

Vladimir Reinharz (V)

Department of Computer Science, Université du Québec à Montréal, Montréal, QC H3C 3P8, Canada.

Jeffrey S Glenn (JS)

Division of Gastroenterology and Hepatology, Departments of Medicine, Microbiology & Immunology, Stanford School of Medicine, Stanford, CA 94305, USA.

Ohad Etzion (O)

Department of Gastroenterology and Liver Diseases, Soroka University Medical Center, Beer-Sheva 84101, Israel.

Scott J Cotler (SJ)

The Program for Experimental and Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 84101, USA.

Cihan Yurdaydin (C)

Department of Gastroenterology and Hepatology, Koç University Medical School, Istanbul 34450, Turkey.

Danny Barash (D)

Department of Computer Science, Ben-Gurion University, Beer-Sheva 84105, Israel.

Harel Dahari (H)

The Program for Experimental and Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 84101, USA.

Classifications MeSH