Photochemical control of drug efficacy - a comparison of uncaging and photoswitching ifenprodil on NMDA receptors.
Journal
ChemPhotoChem
ISSN: 2367-0932
Titre abrégé: ChemPhotoChem
Pays: Germany
ID NLM: 101704340
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
entrez:
21
12
2022
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
ppublish
Résumé
Ifenprodil is an important negative allosteric modulator of the N-methyl-D-aspartate (NMDA) receptors. We have synthesized caged and photoswitchable derivatives of this small molecule drug. Caged ifenprodil was biologically inert before photolysis, UV irradiation efficiently released the drug allowing selective inhibition of GluN2B-containing NMDA receptors. Azobenzene-modified ifenprodil, on the other hand, is inert in both its
Identifiants
pubmed: 36540756
doi: 10.1002/cptc.202000240
pmc: PMC9762817
mid: NIHMS1793014
doi:
Types de publication
Journal Article
Langues
eng
Pagination
445-454Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM053395
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS111600
Pays : United States
Déclaration de conflit d'intérêts
Conflicts of interest. None.
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