Immune mechanisms in fibrotic pulmonary sarcoidosis.
Journal
European respiratory review : an official journal of the European Respiratory Society
ISSN: 1600-0617
Titre abrégé: Eur Respir Rev
Pays: England
ID NLM: 9111391
Informations de publication
Date de publication:
31 Dec 2022
31 Dec 2022
Historique:
received:
04
09
2022
accepted:
21
10
2022
entrez:
21
12
2022
pubmed:
22
12
2022
medline:
24
12
2022
Statut:
epublish
Résumé
Sarcoidosis is an immune-mediated disorder. Its immunopathology has been steadily mapped out over the past few decades. Despite this, the underpinning mechanisms for progressive fibrotic sarcoidosis is an almost uncharted area. Consequently, there has been little change in the clinical management of fibrotic sarcoidosis over the decades and an unfocused search for new therapeutics. In this review, we provide a comprehensive examination of the relevant immune findings in fibrotic and/or progressive pulmonary sarcoidosis and propose a unifying mechanism for the pathobiology of fibrosis in sarcoidosis.
Identifiants
pubmed: 36543347
pii: 31/166/220178
doi: 10.1183/16000617.0178-2022
pmc: PMC9879330
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : R41 HL129728
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright ©The authors 2022.
Déclaration de conflit d'intérêts
Conflict of interest: P. Weeratunga has received support for the present manuscript from the University of Oxford Nuffield Department of Medicine Studentship. Conflict of interest: D.R. Moller has received support for the present manuscript from the National Heart, Lung and Blood Institute, payments made to Johns Hopkins. Royalties or licenses outside the submitted work: Hodder Education for editing a book on sarcoidosis, Taylor and Francis Group for editing a book on ILD. Consulting fees received outside the submitted work from: Roivant and SarcoMed. Speaker fees received from the Trinity Postgraduate Respiratory Conference, outside the submitted work. Patents planned, issued or pending: Patent No. 9,683,999 B2 (issued, not licensed or royalties), Patent No. 9,977,029 B2 (issued, not licensed or royalties), Patent No. 11,041,862 B2 (issued, not licensed or royalties), Patent Application No. 17/319,211 (pending, not licensed or royalties). Leadership or fiduciary role in other board, society, committee or advocacy group, paid or unpaid: Foundation for Sarcoidosis Research (former member of Scientific Advisory Board, unpaid). Other financial or non-financial interests: Chairman and Chief Technical Officer for Sarcoidosis Diagnostic Testing, LLC, the company goal is to develop a diagnostic blood test for sarcoidosis and the company has received funding including past salary support under the NHLBI STTR program, grant R41 HL129728 over 3 years ago. Conflict of interest: L-P. Ho has received support for the present manuscript from Medical Research Council core funding.
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