Multi-omics insights into the biological mechanisms underlying statistical gene-by-lifestyle interactions with smoking and alcohol consumption.
alcohol
blood pressure
gene-lifestyle interactions
multi-omics
serum lipids
smoking
summary data
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2022
2022
Historique:
received:
27
05
2022
accepted:
18
11
2022
entrez:
22
12
2022
pubmed:
23
12
2022
medline:
23
12
2022
Statut:
epublish
Résumé
Though both genetic and lifestyle factors are known to influence cardiometabolic outcomes, less attention has been given to whether lifestyle exposures can alter the association between a genetic variant and these outcomes. The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium's Gene-Lifestyle Interactions Working Group has recently published investigations of genome-wide gene-environment interactions in large multi-ancestry meta-analyses with a focus on cigarette smoking and alcohol consumption as lifestyle factors and blood pressure and serum lipids as outcomes. Further description of the biological mechanisms underlying these statistical interactions would represent a significant advance in our understanding of gene-environment interactions, yet accessing and harmonizing individual-level genetic and 'omics data is challenging. Here, we demonstrate the coordinated use of summary-level data for gene-lifestyle interaction associations on up to 600,000 individuals, differential methylation data, and gene expression data for the characterization and prioritization of loci for future follow-up analyses. Using this approach, we identify 48 genes for which there are multiple sources of functional support for the identified gene-lifestyle interaction. We also identified five genes for which differential expression was observed by the same lifestyle factor for which a gene-lifestyle interaction was found. For instance, in gene-lifestyle interaction analysis, the T allele of rs6490056 (
Identifiants
pubmed: 36544485
doi: 10.3389/fgene.2022.954713
pii: 954713
pmc: PMC9760722
doi:
Types de publication
Journal Article
Langues
eng
Pagination
954713Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL156991
Pays : United States
Informations de copyright
Copyright © 2022 Majarian, Bentley, Laville, Brown, Chasman, de Vries, Feitosa, Franceschini, Gauderman, Marchek, Levy, Morrison, Province, Rao, Schwander, Sung, Rotimi, Aschard, Gu and Manning.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Nicotine Tob Res. 2013 Mar;15(3):622-32
pubmed: 22990226
Tob Control. 2021 Sep 16;:
pubmed: 34535507
Obesity (Silver Spring). 2012 Oct;20(10):2147-50
pubmed: 22836686
Nat Genet. 2019 Apr;51(4):636-648
pubmed: 30926973
Nicotine Tob Res. 2011 Sep;13(9):772-83
pubmed: 21546441
JAMA. 1998 Jul 8;280(2):152-6
pubmed: 9669788
Tob Control. 2015 Jan;24(1):28-37
pubmed: 23997070
Science. 2015 Jan 23;347(6220):1260419
pubmed: 25613900
BMC Med Genomics. 2017 Oct 6;10(1):58
pubmed: 28985737
Am J Hum Genet. 2017 Dec 7;101(6):888-902
pubmed: 29198723
Cancer Epidemiol Biomarkers Prev. 2016 Jun;25(6):936-43
pubmed: 27030603
Am J Public Health. 2015 Sep;105(9):e8-18
pubmed: 26180986
Circ Cardiovasc Genet. 2017 Jun;10(3):
pubmed: 28620071
Nat Genet. 2012 May 13;44(6):659-69
pubmed: 22581228
Am J Hum Genet. 2018 Mar 01;102(3):375-400
pubmed: 29455858
Am J Cardiol. 2004 May 15;93(10):1238-42
pubmed: 15135696
Am J Epidemiol. 2019 Jun 1;188(6):1033-1054
pubmed: 30698716
Eur J Hum Genet. 2022 Jun;30(6):730-739
pubmed: 35314805
Fertil Steril. 2020 Sep;114(3):646-652
pubmed: 32682516
Circ Cardiovasc Genet. 2016 Oct;9(5):436-447
pubmed: 27651444
Hum Mol Genet. 2019 Aug 1;28(15):2615-2633
pubmed: 31127295
Nicotine Tob Res. 2014 May;16(5):600-5
pubmed: 24297808
Mol Pharmacol. 2015 Aug;88(2):256-64
pubmed: 25964258
Am J Hypertens. 2015 Mar;28(3):343-54
pubmed: 25189868
J Biol Chem. 2000 Apr 14;275(15):11106-13
pubmed: 10753916
PLoS Genet. 2019 Feb 15;15(2):e1007916
pubmed: 30768591
Neuron. 2000 Oct;28(1):53-67
pubmed: 11086983
Nat Commun. 2017 Jun 01;8:15080
pubmed: 28569747
Am J Hypertens. 2016 Aug;29(8):891-9
pubmed: 27037711
Free Radic Res. 2017 Apr;51(4):428-438
pubmed: 28427291
J Hypertens. 2009 Mar;27(3):491-501
pubmed: 19330903
Hypertension. 2017 Oct;70(4):660-667
pubmed: 28784646
Nat Genet. 2013 Jun;45(6):580-5
pubmed: 23715323
PLoS One. 2018 Jun 18;13(6):e0198166
pubmed: 29912962
Metab Syndr Relat Disord. 2012 Aug;10(4):252-9
pubmed: 22385338
Front Psychiatry. 2011 Mar 08;2:5
pubmed: 21556275
Oncotarget. 2019 Aug 06;10(47):4857-4867
pubmed: 31448052
J Am Coll Cardiol. 2005 Aug 2;46(3):464-9
pubmed: 16053959
MMWR Recomm Rep. 1998 Oct 9;47(RR-18):v-xv, 1-16
pubmed: 9784089
Curr Genomics. 2017 Aug;18(4):332-340
pubmed: 29081689
SSM Popul Health. 2019 May 08;7:100391
pubmed: 31193191
Proc Jpn Acad Ser B Phys Biol Sci. 2019;95(2):53-66
pubmed: 30745502
Physiol Rev. 2014 Jan;94(1):1-34
pubmed: 24382882
Hum Mol Genet. 2016 Nov 1;25(21):4611-4623
pubmed: 28158590
Genome Biol. 2016 Jun 27;17(1):138
pubmed: 27350042
Oxid Med Cell Longev. 2017;2017:8319176
pubmed: 28250893
Neurosci Res. 2003 Feb;45(2):219-24
pubmed: 12573468
Environ Int. 2018 Apr;113:249-258
pubmed: 29459183
Lipids Health Dis. 2012 Nov 05;11:150
pubmed: 23122449
Mol Psychiatry. 2018 Feb;23(2):422-433
pubmed: 27843151
Environ Toxicol Pharmacol. 2015 Sep;40(2):471-9
pubmed: 26282484
J Clin Endocrinol Metab. 2008 Jun;93(6):2294-9
pubmed: 18364377