Toxicity of bisphenol A and its replacements in the mice Leydig cells in vitro.
Journal
Physiological research
ISSN: 1802-9973
Titre abrégé: Physiol Res
Pays: Czech Republic
ID NLM: 9112413
Informations de publication
Date de publication:
08 03 2023
08 03 2023
Historique:
pubmed:
23
12
2022
medline:
11
3
2023
entrez:
22
12
2022
Statut:
ppublish
Résumé
The aim of the study was to examine the potential impacts of bisphenol A (BPA) and its analogues BPB, BPF, and BPS on mice TM3 Leydig cells, with respect to basal cell viability parameters such as metabolic activity, cell membrane integrity, and lysosomal activity after 48-h exposure. In addition, monitoring of potential bisphenol´s actions included evaluation of ROS production and gap junctional intercellular communication (GJIC) complemented by determination of testosterone secretion. Obtained results revealed significant inhibition in mitochondrial activity started at 10 microg/ml of bisphenols after 48-h exposure. Cell membrane integrity was significantly decreased at 5 microg/ml of BPA and BPF and 10, 25, and 50 microg/ml of BPA and BPS. The lysosomal activity was significantly affected at 10, 25, and 50 microg/ml of applied bisphenols. A significant overproduction of ROS was recorded mainly at 5 and 10 microg/ml of tested compounds. In addition, significant inhibition of GJIC was observed at 5 microg/ml of BPB followed by a progressive decline at higher applied doses. In the case of testosterone production, a significant decline was confirmed at 10, 25 and 50 microg/ml.
Identifiants
pubmed: 36545881
pii: 934989
doi: 10.33549/physiolres.934989
pmc: PMC10069807
Substances chimiques
bisphenol A
MLT3645I99
Reactive Oxygen Species
0
Endocrine Disruptors
0
Sulfones
0
Testosterone
3XMK78S47O
Benzhydryl Compounds
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
71-86Références
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