Endocardium in Hypoplastic Left Heart Syndrome: Implications from In Vitro Study.
endocardium
hypoplastic left heart syndrome
in vitro study
induced pluripotent stem cell (iPSC)
Journal
Journal of cardiovascular development and disease
ISSN: 2308-3425
Titre abrégé: J Cardiovasc Dev Dis
Pays: Switzerland
ID NLM: 101651414
Informations de publication
Date de publication:
08 Dec 2022
08 Dec 2022
Historique:
received:
28
11
2022
revised:
06
12
2022
accepted:
06
12
2022
entrez:
22
12
2022
pubmed:
23
12
2022
medline:
23
12
2022
Statut:
epublish
Résumé
Endocardium lines the inner layer of the heart ventricle and serves as the source of valve endothelial cells and interstitial cells. Previously, endocardium-associated abnormalities in hypoplastic left heart syndrome (HLHS) have been reported, including endocardial fibroelastosis (EFE) and mitral and aortic valve malformation. However, few mechanistic studies have investigated the molecular pathological changes in endocardial cells. Recently, the emergence of a powerful in vitro system-induced pluripotent stem cells (iPSCs)-was applied to study various genetic diseases, including HLHS. This review summarized current in vitro studies in understanding the endocardial pathology in HLHS, emphasizing new findings of the cellular phenotypes and underlying molecular mechanisms. Lastly, a future perspective is provided regarding the better recapitulation of endocardial phenotypes in a dish.
Identifiants
pubmed: 36547439
pii: jcdd9120442
doi: 10.3390/jcdd9120442
pmc: PMC9786329
pii:
doi:
Types de publication
Journal Article
Langues
eng
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