Correlation of angiogenic growth factors and inflammatory cytokines with the clinical phenotype of ocular tuberculosis.
Angiopoietin
Growth factors
Inflammatory cytokines
Ocular tuberculosis
Serpiginous like choroiditis
Uveitis
Journal
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
ISSN: 1435-702X
Titre abrégé: Graefes Arch Clin Exp Ophthalmol
Pays: Germany
ID NLM: 8205248
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
received:
21
07
2022
accepted:
26
11
2022
revised:
08
11
2022
medline:
1
5
2023
pubmed:
23
12
2022
entrez:
22
12
2022
Statut:
ppublish
Résumé
To determine the correlation of angiogenic growth factors and inflammatory cytokines with the clinical phenotype of ocular tuberculosis (OTB). Vitreous fluid was analysed for cytokines in patients with OTB and non-OTB uveitis using multiplex fluorescent bead-based flow cytometric assay. The clinical phenotypes were recorded and correlated with vitreous biomarkers. Vitreous humour from OTB patients had elevated levels of interleukin-10 (IL-10), IL-17-A, interferon-gamma (IFN-γ), and tumour necrosis factor-alpha (TNF-α). Angiopoietin (Ang-2) levels were higher in the panuveitis phenotype. OTB posterior uveitis phenotype had relatively higher vascular endothelial growth factor (VEGF) levels and lower fibroblast growth factor (FGF) levels. Additionally, eyes with choroiditis and vasculitis had elevated levels of VEGF and Ang-2 with FGF downregulation. Both IFN-γ and IL-10 were upregulated in the choroiditis phenotype of OTB. Angiogenic growth factors and inflammatory cytokines were altered in the vitreous humour of OTB patients. IFN-γ, VEGF, and IL-10 levels are increased in choroiditis and vasculitis phenotypes. Receiver operating characteristic (ROC) curve analysis further emphasized the importance of the IFN-γ assay in the diagnosis of OTB.
Identifiants
pubmed: 36547708
doi: 10.1007/s00417-022-05943-9
pii: 10.1007/s00417-022-05943-9
doi:
Substances chimiques
Cytokines
0
Interleukin-10
130068-27-8
Vascular Endothelial Growth Factor A
0
Intercellular Signaling Peptides and Proteins
0
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1369-1380Subventions
Organisme : Department of Biotechnology, Ministry of Science and Technology, India
ID : BT/PR13453/MED/30/1524/2015
Organisme : Indian Council of Medical Research
ID : 2015-1323 NCD II
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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