Unprecedented Relaxivity Gap in pH-Responsive Fe
Detection Sensitivity
Iron(III) Chelates
Molecular MRI
Relaxivity
pH-Responsive Molecular Probes
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
06 Feb 2023
06 Feb 2023
Historique:
received:
30
08
2022
pubmed:
23
12
2022
medline:
23
12
2022
entrez:
22
12
2022
Statut:
ppublish
Résumé
Two mononuclear ferric complexes are reported that respond to a pH change with a 27- and 71-fold jump, respectively, in their capacity to accelerate the longitudinal relaxation rate of water-hydrogen nuclei, and this starting from a negligible base value of only 0.06. This unprecedented performance bodes well for tackling the sensitivity issues hampering the development of Molecular MRI. The two chelates also excel in the fully reversible and fatigue-less nature of this phenomenon. The structural reasons for this performance reside in the macrocyclic nature of the hexa-dentate ligand, as well as the presence of a single pendant arm displaying a five-membered lactam or carbamate which show (perturbed) pK
Identifiants
pubmed: 36548129
doi: 10.1002/anie.202212782
pmc: PMC10107872
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202212782Informations de copyright
© 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.
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