Distinct Metabolic States Are Observed in Hypoglycemia Induced in Mice by Ricin Toxin or by Fasting.
1H-NMR
Kennedy pathway
fasting
hypoglycemia
liver
metabolomics
multivariate analysis
ricin
toxin
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
22 11 2022
22 11 2022
Historique:
received:
18
10
2022
revised:
08
11
2022
accepted:
15
11
2022
entrez:
22
12
2022
pubmed:
23
12
2022
medline:
27
12
2022
Statut:
epublish
Résumé
Hypoglycemia may be induced by a variety of physiologic and pathologic stimuli and can result in life-threatening consequences if untreated. However, hypoglycemia may also play a role in the purported health benefits of intermittent fasting and caloric restriction. Previously, we demonstrated that systemic administration of ricin toxin induced fatal hypoglycemia in mice. Here, we examine the metabolic landscape of the hypoglycemic state induced in the liver of mice by two different stimuli: systemic ricin administration and fasting. Each stimulus produced the same decrease in blood glucose and weight loss. The polar metabolome was studied using
Identifiants
pubmed: 36548712
pii: toxins14120815
doi: 10.3390/toxins14120815
pmc: PMC9782143
pii:
doi:
Substances chimiques
Blood Glucose
0
Ricin
9009-86-3
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK117473
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI136758
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR026659
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI127398
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI059376
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01DK117473
Pays : United States
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