HPMA copolymer conjugated 5-aminolevulinic acid exhibits superior efficacy for photodynamic therapy with tumor-responsive and targeting properties.
5-Aminolevulinic acid
EPR effect
HPMA copolymer
Photodynamic therapy
Tumor targeting
Journal
Nanomedicine : nanotechnology, biology, and medicine
ISSN: 1549-9642
Titre abrégé: Nanomedicine
Pays: United States
ID NLM: 101233142
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
received:
15
09
2022
revised:
21
11
2022
accepted:
13
12
2022
pubmed:
23
12
2022
medline:
15
2
2023
entrez:
22
12
2022
Statut:
ppublish
Résumé
In this study, we developed a nanoformulation of 5-aminolevulinic acid (5-ALA) for tumor-targeted photodynamic therapy, in which 5-ALA was conjugated with a biocompatible polymer N-(2-hydroxypropyl)methacrylamide (HPMA) through the hydrazone bond, i.e., P-ALA. P-ALA behaves as the nano-sized molecule with an average size of 5.5 nm in aqueous solution. P-ALA shows a largely increased release rate in acidic pH than physiological pH, suggesting the rapid release profile in acidic tumor environment. P-ALA did not show apparent cytotoxicity up to 0.1 mg/ml, however, under light irradiation, remarkable cell death was induced with the IC
Identifiants
pubmed: 36549553
pii: S1549-9634(22)00122-8
doi: 10.1016/j.nano.2022.102636
pii:
doi:
Substances chimiques
Aminolevulinic Acid
88755TAZ87
Antineoplastic Agents
0
hydroxypropyl methacrylate
UKW89XAX2X
Doxorubicin
80168379AG
Polymers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102636Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of interest The authors declare no conflict of interest.