Sulfotransferase 2B1b, Sterol Sulfonation, and Disease.
Journal
Pharmacological reviews
ISSN: 1521-0081
Titre abrégé: Pharmacol Rev
Pays: United States
ID NLM: 0421737
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
received:
06
07
2022
revised:
18
10
2022
accepted:
07
12
2022
pmc-release:
01
05
2024
medline:
25
4
2023
pubmed:
23
12
2022
entrez:
22
12
2022
Statut:
ppublish
Résumé
The primary function of human sulfotransferase 2B1b (SULT2B1b) is to sulfonate cholesterol and closely related sterols. SULT2B1b sterols perform a number of essential cellular functions. Many are signaling molecules whose activities are redefined by sulfonation-allosteric properties are switched "on" or "off," agonists are transformed into antagonists, and vice versa. Sterol sulfonation is tightly coupled to cholesterol homeostasis, and sulfonation imbalances are causally linked to cholesterol-related diseases including certain cancers, Alzheimer disease, and recessive X-linked ichthyosis-an orphan skin disease. Numerous studies link SULT2B1b activity to disease-relevant molecular processes. Here, these multifaceted processes are integrated into metabolic maps that highlight their interdependence and how their actions are regulated and coordinated by SULT2B1b oxysterol sulfonation. The maps help explain why SULT2B1b inhibition arrests the growth of certain cancers and make the novel prediction that SULT2B1b inhibition will suppress production of amyloid
Identifiants
pubmed: 36549865
pii: pharmrev.122.000679
doi: 10.1124/pharmrev.122.000679
pmc: PMC10158503
doi:
Substances chimiques
Sterols
0
Amyloid beta-Peptides
0
Sulfotransferases
EC 2.8.2.-
Sulfates
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
521-531Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM127144
Pays : United States
Informations de copyright
Copyright © 2023 by The American Society for Pharmacology and Experimental Therapeutics.
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