Peripheral quantitative computed tomography-derived bone parameters in men with impaired fasting glucose and diabetes.
Impaired fasting glucose
Men
Peripheral quantitative computed tomography
Type 2 diabetes
Journal
Journal of bone and mineral metabolism
ISSN: 1435-5604
Titre abrégé: J Bone Miner Metab
Pays: Japan
ID NLM: 9436705
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
received:
17
08
2022
accepted:
13
11
2022
pubmed:
23
12
2022
medline:
3
2
2023
entrez:
22
12
2022
Statut:
ppublish
Résumé
Individuals with type 2 diabetes mellitus (T2DM) are at higher risk of fracture, but paradoxically do not have reduced bone mineral density. We investigated associations between peripheral quantitative computed tomography (pQCT) and glycaemia status. Participants were men (n = 354, age 33-92 year) from the Geelong Osteoporosis Study. Diabetes was defined by fasting plasma glucose (FPG) ≥ 7.0 mmol/L, self-report of diabetes and/or antihyperglycaemic medication use and impaired fasting glucose (IFG) as FPG 5.6-6.9 mmol/L. Bone measures were derived using pQCT (XCT2000) at 4% and 66% radial and tibial sites. Linear regression was used, adjusting for age, body mass index and socio-economic status. At the 4% site, men with T2DM had lower adjusted bone total area, trabecular area and cortical area at the radius (all - 6.2%) and tibia (all - 6.4%) compared to normoglycaemia. Cortical density was higher for T2DM at the radius (+ 5.8%) and tibia (+ 8.0%), as well as adjusted total bone density at the tibial site (+ 6.1%). At the 66% site, adjusted total bone area and polar stress strain index were lower for T2DM at the radius (- 4.3% and - 8.0%). Total density was also higher for T2DM (+ 1.2%). Only cortical density at the 4% tibial site was different between IFG and normoglycaemia in adjusted analyses (+ 4.5%). Men with T2DM had lower total bone area, trabecular area, cortical area and polar stress strain index than the other two groups; however, total density and cortical density were higher. Only one difference was observed between IFG and normoglycaemia; increased tibial cortical density.
Identifiants
pubmed: 36550385
doi: 10.1007/s00774-022-01389-5
pii: 10.1007/s00774-022-01389-5
doi:
Substances chimiques
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
131-142Subventions
Organisme : National Health and Medical Research Council
ID : 299831
Organisme : National Health and Medical Research Council
ID : 628582
Organisme : Deakin University
ID : Alfred Deakin Postdoctoral Research Fellowship
Organisme : Deakin University
ID : Australian Government Research Training Program Scholarship
Organisme : Deakin University
ID : Deakin Postgraduate Scholarship
Organisme : Deakin University
ID : Dean's Research Postdoctoral Fellowship
Organisme : Deakin University
ID : Deakin University Postgraduate Research Scholarship
Informations de copyright
© 2022. The Japanese Society Bone and Mineral Research.
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