A Comparison Study of the Detection Limit of Omicron SARS-CoV-2 Nucleocapsid by Various Rapid Antigen Tests.
COVID-19
SARS-CoV-2
omicron variant
rapid antigen test
Journal
Biosensors
ISSN: 2079-6374
Titre abrégé: Biosensors (Basel)
Pays: Switzerland
ID NLM: 101609191
Informations de publication
Date de publication:
27 Nov 2022
27 Nov 2022
Historique:
received:
25
10
2022
revised:
23
11
2022
accepted:
24
11
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
27
12
2022
Statut:
epublish
Résumé
Rapid antigen tests (RATs) are widely used worldwide to detect SARS-CoV-2 since they are an easy-to-use kit and offer rapid results. The RAT detects the presence of the nucleocapsid protein, which is located inside the virus. However, the sensitivity of the different RATs varies between commercially available kits. The test result might change due to various factors, such as the variant type, infection date, swab's surface, the manner in which one performs the testing and the mucus components. Here, we compare the detection limit of seven commercially available RATs by introducing them to known SARS-CoV-2 nucleocapsid protein amounts from the Omicron variant. It allows us to determine the detection limit, disregarding the influences of other factors. A lower detection limit of the RAT is necessary since earlier detection will help reduce the spread of the virus and allow faster treatment, which might be crucial for the population at risk.
Identifiants
pubmed: 36551050
pii: bios12121083
doi: 10.3390/bios12121083
pmc: PMC9775131
pii:
doi:
Substances chimiques
Nucleocapsid Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Israel Science Foundation
ID : 3970/19
Références
Sci Rep. 2021 Sep 15;11(1):18313
pubmed: 34526517
Med Microbiol Immunol. 2022 Jun;211(2-3):105-117
pubmed: 35187580
Lancet Infect Dis. 2022 Feb;22(2):183-195
pubmed: 34756186
Essays Biochem. 2016 Jun 30;60(1):111-20
pubmed: 27365041
Travel Med Infect Dis. 2022 Jan-Feb;45:102234
pubmed: 34896326
Biosens Bioelectron. 2016 May 15;79:98-107
pubmed: 26700582
Cochrane Database Syst Rev. 2022 Jul 22;7:CD013705
pubmed: 35866452
JAMA Intern Med. 2022 Jul 1;182(7):701-709
pubmed: 35486394
Int J Infect Dis. 2020 Oct;99:328-333
pubmed: 32497809
Nat Commun. 2021 Jan 21;12(1):502
pubmed: 33479198
Biosensors (Basel). 2022 Jun 13;12(6):
pubmed: 35735558
Biosensors (Basel). 2022 Aug 13;12(8):
pubmed: 36005033
Lancet Respir Med. 2020 May;8(5):434-436
pubmed: 32203710
Clin Microbiol Infect. 2021 Feb;27(2):289.e1-289.e4
pubmed: 33031947
BMC Med. 2020 Jul 30;18(1):240
pubmed: 32727547
J Chem Inf Model. 2022 Jan 24;62(2):412-422
pubmed: 34989238
Nat Commun. 2020 Nov 18;11(1):5885
pubmed: 33208793
Analyst. 2021 Jun 14;146(12):3750-3776
pubmed: 34060546
Lancet. 2020 Apr 25;395(10233):1315
pubmed: 32334687
Analyst. 2021 Jan 21;146(2):382-402
pubmed: 33410826
J Clin Virol. 2020 Aug;129:104500
pubmed: 32585619
Nature. 2020 Jul;583(7817):506-509
pubmed: 32681157
Nat Med. 2022 Jul;28(7):1491-1500
pubmed: 35395151
J Clin Microbiol. 2022 May 18;60(5):e0014022
pubmed: 35440165
Anal Chem. 2020 Jul 7;92(13):9399-9404
pubmed: 32438806
Emerg Infect Dis. 2004 Nov;10(11):1947-9
pubmed: 15550204
Viruses. 2021 Jun 10;13(6):
pubmed: 34200602
Research (Wash D C). 2020 Aug 7;2020:7286735
pubmed: 32832908
Anal Chem. 2022 Jan 11;94(1):3-25
pubmed: 34874149