Heparan Sulfate Proteoglycans in Tauopathy.
Alzheimer’s disease
heparan sulfate proteoglycan
tau
tauopathy
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
30 11 2022
30 11 2022
Historique:
received:
20
11
2022
revised:
28
11
2022
accepted:
28
11
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
27
12
2022
Statut:
epublish
Résumé
Tauopathies are a class of neurodegenerative diseases, including Alzheimer's disease, and are characterized by intraneuronal tau inclusion in the brain and the patient's cognitive decline with obscure pathogenesis. Heparan sulfate proteoglycans, a major type of extracellular matrix, have been believed to involve in tauopathies. The heparan sulfate proteoglycans co-deposit with tau in Alzheimer's patient brain, directly bind to tau and modulate tau secretion, internalization, and aggregation. This review summarizes the current understanding of the functions and the modulated molecular pathways of heparan sulfate proteoglycans in tauopathies, as well as the implication of dysregulated heparan sulfate proteoglycan expression in tau pathology and the potential of targeting heparan sulfate proteoglycan-tau interaction as a novel therapeutic option.
Identifiants
pubmed: 36551220
pii: biom12121792
doi: 10.3390/biom12121792
pmc: PMC9776397
pii:
doi:
Substances chimiques
Heparan Sulfate Proteoglycans
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : RF1 AG074289
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG057464
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG062344
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG069039
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016086
Pays : United States
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