When and How to Use MIC in Clinical Practice?
PK/PD parameters
TDM-guided dosing adjustment
clinical practice
microbiology
minimal inhibitory concentration
pharmacology
Journal
Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404
Informations de publication
Date de publication:
03 Dec 2022
03 Dec 2022
Historique:
received:
18
10
2022
revised:
22
11
2022
accepted:
30
11
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
24
12
2022
Statut:
epublish
Résumé
Bacterial resistance to antibiotics continues to be a global public health problem. The choice of the most effective antibiotic and the use of an adapted dose in the initial phase of the infection are essential to limit the emergence of resistance. This will depend on (i) the isolated bacteria and its resistance profile, (ii) the pharmacodynamic (PD) profile of the antibiotic used and its level of toxicity, (iii) the site of infection, and (iv) the pharmacokinetic (PK) profile of the patient. In order to take account of both parameters to optimize the administered treatment, a minimal inhibitory concentration (MIC) determination associated with therapeutic drug monitoring (TDM) and their combined interpretation are required. The objective of this narrative review is thus to suggest microbiological, pharmacological, and/or clinical situations for which this approach could be useful. Regarding the microbiological aspect, such as the detection of antibiotic resistance and its level, the preservation of broad-spectrum β-lactams is particularly discussed. PK-PD profiles are relevant for difficult-to-reach infections and specific populations such as intensive care patients, cystic fibrosis patients, obese, or elderly patients. Finally, MIC and TDM are tools available to clinicians, who should not hesitate to use them to manage their patients.
Identifiants
pubmed: 36551405
pii: antibiotics11121748
doi: 10.3390/antibiotics11121748
pmc: PMC9774413
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Antibiotics (Basel). 2022 Oct 10;11(10):
pubmed: 36290042
Clin Pharmacokinet. 2004;43(13):925-42
pubmed: 15509186
Int J Antimicrob Agents. 2022 Jul;60(1):106603
pubmed: 35577257
Antimicrob Agents Chemother. 2019 Apr 25;63(5):
pubmed: 30858212
J Infect Dis. 2017 Feb 15;215(suppl_1):S28-S36
pubmed: 28375512
J Clin Microbiol. 2009 Sep;47(9):2751-8
pubmed: 19571019
Clin Infect Dis. 2012 Jan 15;54(2):175-7
pubmed: 22057699
Antimicrob Agents Chemother. 2013 Mar;57(3):1488-95
pubmed: 23318796
Anaesth Intensive Care. 2015 Sep;43(5):594-9
pubmed: 26310409
Clin Microbiol Rev. 2018 Feb 14;31(2):
pubmed: 29444952
Antimicrob Agents Chemother. 2001 Jun;45(6):1693-9
pubmed: 11353613
Pharmacotherapy. 2010 Dec;30(12):1252-8
pubmed: 21114393
Clin Infect Dis. 2012 Jan 15;54(2):167-74
pubmed: 22057701
J Antimicrob Chemother. 2017 Oct 1;72(10):2891-2897
pubmed: 29091190
Antimicrob Agents Chemother. 2010 Oct;54(10):4360-7
pubmed: 20625153
Antibiotics (Basel). 2022 May 27;11(6):
pubmed: 35740130
Expert Opin Pharmacother. 2008 Jan;9(1):23-37
pubmed: 18076336
Expert Opin Drug Metab Toxicol. 2021 Jan;17(1):53-68
pubmed: 33213220
Antimicrob Agents Chemother. 2022 Aug 16;66(8):e0043822
pubmed: 35862739
J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Nov 15;875(2):546-50
pubmed: 18838314
Clin Infect Dis. 2014 Apr;58(8):1072-83
pubmed: 24429437
Int J Antimicrob Agents. 2017 Jan;49(1):62-66
pubmed: 27876276
Curr Opin Infect Dis. 2008 Oct;21(5):531-8
pubmed: 18725804
Asian Spine J. 2010 Dec;4(2):136-40
pubmed: 21165319
Antibiotics (Basel). 2022 Sep 03;11(9):
pubmed: 36139972
Eur J Clin Microbiol Infect Dis. 2022 Sep;41(9):1183-1190
pubmed: 35984543
Clin Pharmacokinet. 2022 Jun;61(6):895-906
pubmed: 35344155
BMC Infect Dis. 2013 Aug 19;13:380
pubmed: 23957376
Antimicrob Agents Chemother. 2019 Feb 26;63(3):
pubmed: 30602511
Clin Microbiol Infect. 2022 Apr;28(4):521-547
pubmed: 34923128
Crit Care. 2010;14(4):R126
pubmed: 20594297
Expert Opin Drug Metab Toxicol. 2022 Mar;18(3):177-187
pubmed: 35311440
Biomed Pharmacother. 2021 Oct;142:112053
pubmed: 34435591
Br J Clin Pharmacol. 2019 Oct;85(10):2436-2441
pubmed: 31313335
Antimicrob Agents Chemother. 2022 Dec 20;66(12):e0082022
pubmed: 36326246
Clin Microbiol Infect. 2005 Nov;11 Suppl 6:10-7
pubmed: 16209701
Clin Pharmacokinet. 2022 Aug;61(8):1075-1094
pubmed: 35754071
Int J Antimicrob Agents. 2020 Nov;56(5):106158
pubmed: 32919007
Pharmacotherapy. 2021 Feb;41(2):220-233
pubmed: 33480024
J Chromatogr B Analyt Technol Biomed Life Sci. 2020 Nov 20;1158:122397
pubmed: 33091676
Antibiotics (Basel). 2022 Mar 23;11(4):
pubmed: 35453179
Antibiotics (Basel). 2022 Aug 29;11(9):
pubmed: 36139944
Clin Microbiol Infect. 2008 Jan;14 Suppl 1:181-4
pubmed: 18154544
BMC Infect Dis. 2011 Jun 22;11:181
pubmed: 21696619
Clin Infect Dis. 1998 Jul;27(1):23-7
pubmed: 9675444
Antimicrob Agents Chemother. 1993 May;37(5):1073-81
pubmed: 8517694
J Antimicrob Chemother. 2022 Aug 25;77(9):2479-2488
pubmed: 35815604
Intensive Care Med. 2020 Jun;46(6):1127-1153
pubmed: 32383061
Pathogens. 2021 Feb 04;10(2):
pubmed: 33557078
Antibiotics (Basel). 2020 Feb 05;9(2):
pubmed: 32033322
Expert Rev Clin Pharmacol. 2016 Jul;9(7):961-79
pubmed: 27018631
Infection. 2007 Jun;35(4):271-4
pubmed: 17646913
New Microbes New Infect. 2020 Sep 07;37:100755
pubmed: 33014383
Pharmacotherapy. 2019 Jan;39(1):10-39
pubmed: 30710469
Clin Microbiol Rev. 2005 Oct;18(4):657-86
pubmed: 16223952
Antibiotics (Basel). 2022 Mar 08;11(3):
pubmed: 35326825
Int J Antimicrob Agents. 2019 Jun;53(6):850-854
pubmed: 30851401
Sci Rep. 2019 Oct 29;9(1):15290
pubmed: 31664064
J Antimicrob Chemother. 2005 May;55(5):601-7
pubmed: 15772142
Surg Infect (Larchmt). 2021 Jun;22(5):477-484
pubmed: 33146587
F1000 Med Rep. 2012;4:4
pubmed: 22312414
Crit Care. 2019 Mar 29;23(1):104
pubmed: 30925922
Ann Intensive Care. 2022 Sep 30;12(1):90
pubmed: 36175707
J Antimicrob Chemother. 2019 Oct 1;74(10):2825-2843
pubmed: 31170287
J Infect Chemother. 2002 Mar;8(1):50-8
pubmed: 11957120
Antimicrob Agents Chemother. 2013 Jul;57(7):3402-4
pubmed: 23612190
JAMA. 1998 Jan 14;279(2):125-9
pubmed: 9440662
Am J Health Syst Pharm. 2020 May 19;77(11):835-864
pubmed: 32191793
BMJ Case Rep. 2017 Oct 19;2017:
pubmed: 29054948
Infect Dis Ther. 2021 Dec;10(4):1989-2034
pubmed: 34379310
Clin Infect Dis. 2011 Apr 15;52(8):975-81
pubmed: 21460309
Clin Microbiol Infect. 1998 May;4(5):291
pubmed: 11864348
Intensive Care Med. 2014 Jul;40(7):998-1005
pubmed: 24687298
Clin Pharmacokinet. 2018 Sep;57(9):1107-1121
pubmed: 29441476
J Clin Microbiol. 2022 Jun 15;60(6):e0009822
pubmed: 35607972
J Infect Dis. 1987 Jan;155(1):93-9
pubmed: 3540140
Clin Infect Dis. 1998 Jan;26(1):1-10; quiz 11-2
pubmed: 9455502
Ther Drug Monit. 2022 Feb 1;44(1):75-85
pubmed: 34750337
Clin Pharmacokinet. 2003;42(15):1411-23
pubmed: 14674791
Clin Microbiol Infect. 2017 Jul;23(7):454-459
pubmed: 28111294
Infect Dis Clin North Am. 2020 Dec;34(4):773-819
pubmed: 33011051
Antimicrob Agents Chemother. 2017 Aug 24;61(9):
pubmed: 28717035
Clin Pharmacokinet. 2021 Mar;60(3):271-281
pubmed: 33313994
Clin Infect Dis. 2003 Jul 1;37(1):75-81
pubmed: 12830411
Ther Drug Monit. 2022 Dec 1;44(6):709-719
pubmed: 35175248
Clin Pharmacol Ther. 2021 Apr;109(4):892-904
pubmed: 33570163
J Antimicrob Chemother. 2009 Mar;63(3):564-7
pubmed: 19168542
Int J Antimicrob Agents. 2018 Apr;51(4):594-600
pubmed: 29277531
J Antimicrob Chemother. 2008 Jul;62(1):168-71
pubmed: 18334494
J Antimicrob Chemother. 2014 Jan;69(1):176-9
pubmed: 23869050
Chest. 2009 Nov;136(5):1237-1248
pubmed: 19696123
Intern Med J. 2018 Nov;48(11):1294-1307
pubmed: 30387309
Clin Infect Dis. 2021 Dec 6;73(11):e3842-e3850
pubmed: 33106863
Antimicrob Agents Chemother. 2004 Jun;48(6):2244-50
pubmed: 15155228
Clin Microbiol Infect. 2022 Sep;28(9):1211-1224
pubmed: 35429656
Crit Care. 2013 Jul 25;17(4):R165
pubmed: 23886243
Talanta. 2020 Apr 1;210:120619
pubmed: 31987193
Future Microbiol. 2012 Mar;7(3):395-410
pubmed: 22393892
Antimicrob Agents Chemother. 2013 Oct;57(10):5131-3
pubmed: 23836188