Synthesis, Physicochemical Properties and Molecular Docking of New Benzothiazole Derivatives as Antimicrobial Agents Targeting DHPS Enzyme.
antimicrobial evaluation
benzothiazole
docking study
physicochemical properties
sulfonamide
Journal
Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404
Informations de publication
Date de publication:
11 Dec 2022
11 Dec 2022
Historique:
received:
18
11
2022
revised:
07
12
2022
accepted:
08
12
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
24
12
2022
Statut:
epublish
Résumé
The drug-resistance problem is widely spread and becoming more common in community-acquired and nosocomial strains of bacteria. Therefore, finding new antimicrobial agents remains an important drug target. From this perspective, new derivatives of benzothiazole were synthesized and evaluated for their antimicrobial activity and ability to inhibit the DHPS enzyme. The synthesis was carried out by the reaction of benzothiazole
Identifiants
pubmed: 36551457
pii: antibiotics11121799
doi: 10.3390/antibiotics11121799
pmc: PMC9774648
pii:
doi:
Types de publication
Journal Article
Langues
eng
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