A Critical Role of the IL-22-IL-22 Binding Protein Axis in Hepatocellular Carcinoma.
IL-22
IL-22BP
Th22
hepatocellular carcinoma
neutrophils
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
07 Dec 2022
07 Dec 2022
Historique:
received:
18
10
2022
revised:
22
11
2022
accepted:
24
11
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
24
12
2022
Statut:
epublish
Résumé
Hepatocellular carcinoma (HCC) ranks among the five most common cancer entities worldwide and leads to hundred-thousands of deaths every year. Despite some groundbreaking therapeutical revelations during the last years, the overall prognosis remains poor. Although the immune system fights malignant transformations with a robust anti-tumor response, certain immune mediators have also been shown to promote cancer development. For example, interleukin (IL)-22 has been associated with HCC progression and worsened prognosis in multiple studies. However, the underlying mechanisms of the pathological role of IL-22-signaling as well as the role of its natural antagonist IL-22 binding protein (IL-22BP) in HCC remain elusive. Here, we corroborate the pathogenic role of IL-22 in HCC by taking advantage of two mouse models. Moreover, we observed a protective role of IL-22BP during liver carcinogenesis. While IL-22 was mainly produced by CD4
Identifiants
pubmed: 36551508
pii: cancers14246019
doi: 10.3390/cancers14246019
pmc: PMC9775560
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : grant SFB841 and SFB1328
Organisme : European Research Council
ID : CoG 865466
Pays : International
Organisme : Jung Foundation for Science and Research
ID : to S.H.
Organisme : Jung Foundation for Science and Research
ID : to A.D.G.
Organisme : Werner Otto Stiftung
ID : to A.D.G.
Organisme : Erich Und Gertrud Roggenbuck Stiftung
ID : to A.D.G.
Organisme : German Cancer Aid
ID : Nr. 70114853
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