The Gut Microbiome and Its Implication in the Mucosal Digestive Disorders.
digestive pathology
dysbiosis
human
microbiome
probiotics
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
02 Dec 2022
02 Dec 2022
Historique:
received:
31
10
2022
revised:
26
11
2022
accepted:
30
11
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
24
12
2022
Statut:
epublish
Résumé
The gastrointestinal (GI) tract is one of the most studied compartments of the human body as it hosts the largest microbial community including trillions of germs. The relationship between the human and its associated flora is complex, as the microbiome plays an important role in nutrition, metabolism and immune function. With a dynamic composition, influenced by many intrinsic and extrinsic factors, there is an equilibrium maintained in the composition of GI microbiota, translated as "eubiosis". Any disruption of the microbiota leads to the development of different local and systemic diseases. This article reviews the human GI microbiome's composition and function in healthy individuals as well as its involvement in the pathogenesis of different digestive disorders. It also highlights the possibility to consider flora manipulation a therapeutic option when treating GI diseases.
Identifiants
pubmed: 36551874
pii: biomedicines10123117
doi: 10.3390/biomedicines10123117
pmc: PMC9775516
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Gut. 2017 Jun;66(6):1039-1048
pubmed: 26843508
Gastroenterology. 2022 Oct;163(4):908-921
pubmed: 35724733
mBio. 2016 Sep 20;7(5):
pubmed: 27651359
Am J Physiol Gastrointest Liver Physiol. 2001 Mar;280(3):G368-80
pubmed: 11171619
F1000Res. 2020 Jan 31;9:
pubmed: 32051759
Infect Immun. 2016 Apr 22;84(5):1526-1535
pubmed: 26930708
Immunity. 2019 Aug 20;51(2):225-239
pubmed: 31433970
Front Microbiol. 2022 Jan 14;12:791274
pubmed: 35126331
World J Gastroenterol. 2016 Dec 7;22(45):9871-9879
pubmed: 28018095
Cancer Epidemiol Biomarkers Prev. 2019 Oct;28(10):1687-1693
pubmed: 31466948
Front Pharmacol. 2015 Nov 12;6:269
pubmed: 26617521
Sci Rep. 2020 Sep 17;10(1):15250
pubmed: 32943695
Front Pediatr. 2022 Jun 30;10:864397
pubmed: 35844766
Microbiome. 2018 Apr 3;6(1):65
pubmed: 29615108
PLoS One. 2022 Jan 14;17(1):e0262108
pubmed: 35030192
Sci Rep. 2022 Apr 22;12(1):6607
pubmed: 35459889
Gut Microbes. 2013 May-Jun;4(3):181-92
pubmed: 23511582
Genome Med. 2022 Aug 15;14(1):91
pubmed: 35971134
Gastroenterol Hepatol Bed Bench. 2018 Fall;11(4):284-295
pubmed: 30425806
Cell Res. 2020 Jun;30(6):492-506
pubmed: 32433595
Clin Transl Gastroenterol. 2018 May 29;9(5):156
pubmed: 29807991
Transl Res. 2020 Jul;221:23-43
pubmed: 32360945
Microbiome. 2020 Jul 16;8(1):108
pubmed: 32678024
Ann Med. 2021 Dec;53(1):1797-1805
pubmed: 34647492
J Biomed Sci. 2018 Nov 9;25(1):79
pubmed: 30413188
Biosci Rep. 2021 Jun 25;41(6):
pubmed: 34076695
Scand J Gastroenterol. 2018 Jun;53(6):650-656
pubmed: 29616839
Nutrients. 2022 Jul 13;14(14):
pubmed: 35889831
Gastroenterol Clin North Am. 2017 Mar;46(1):121-141
pubmed: 28164846
Dig Dis Sci. 2020 Mar;65(3):695-705
pubmed: 32067143
Antibiotics (Basel). 2019 Dec 13;8(4):
pubmed: 31847278
Front Microbiol. 2019 Jun 04;10:1124
pubmed: 31231319
World J Clin Pediatr. 2021 Sep 9;10(5):84-92
pubmed: 34616650
Trends Microbiol. 2011 Jul;19(7):349-59
pubmed: 21684749
Gut. 2020 Sep;69(9):1598-1607
pubmed: 31857433
Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3779-E3787
pubmed: 29610339
Medicina (Kaunas). 2021 Jun 23;57(7):
pubmed: 34201542
PLoS One. 2015 May 28;10(5):e0128346
pubmed: 26020633
Curr Top Microbiol Immunol. 2017;400:253-275
pubmed: 28124157
Curr Gastroenterol Rep. 2018 Aug 1;20(8):39
pubmed: 30069679
J Nutr Sci Vitaminol (Tokyo). 2015;61 Suppl:S103-5
pubmed: 26598815
Nutr Clin Pract. 2015 Dec;30(6):760-79
pubmed: 26452390
Nature. 2000 Dec 7;408(6813):740-5
pubmed: 11130078
Front Cell Infect Microbiol. 2022 Aug 15;12:953718
pubmed: 36046747
Inflamm Bowel Dis. 2013 Jul;19(8):1598-608
pubmed: 23749273
Viruses. 2022 Jan 28;14(2):
pubmed: 35215871
PeerJ Comput Sci. 2020 Aug 17;6:e289
pubmed: 33816940
Therap Adv Gastroenterol. 2013 Jan;6(1):39-51
pubmed: 23320049
World J Gastroenterol. 2019 May 14;25(18):2149-2161
pubmed: 31143067
Clin Transl Gastroenterol. 2019 Jun;10(6):e00039
pubmed: 31107724
Gastroenterology. 2021 Jan;160(2):524-537
pubmed: 33253681
Curr Treat Options Gastroenterol. 2018 Mar;16(1):72-85
pubmed: 29350339
Semin Pediatr Surg. 2018 Aug;27(4):223-228
pubmed: 30342596
Gut. 2019 Apr;68(4):654-662
pubmed: 30472682
Gastroenterology. 2020 May;158(7):1881-1898
pubmed: 32044317
Neurogastroenterol Motil. 2020 Oct;32(10):e13914
pubmed: 32476236
J Neurogastroenterol Motil. 2020 Apr 30;26(2):171-179
pubmed: 32235026
Gut. 2021 Sep;70(9):1665-1674
pubmed: 33722860
Dis Markers. 2022 Feb 8;2022:2941248
pubmed: 35178126
Cancer Metastasis Rev. 2022 Jun;41(2):281-299
pubmed: 35511379
Am J Physiol Gastrointest Liver Physiol. 2018 Sep 1;315(3):G420-G431
pubmed: 29848021
J Fungi (Basel). 2022 Oct 04;8(10):
pubmed: 36294611
J Gastroenterol Hepatol. 2022 Sep;37(9):1673-1684
pubmed: 35730344
Gut. 2016 Jan;65(1):57-62
pubmed: 26069274
J Pers Med. 2021 Apr 14;11(4):
pubmed: 33919818
J Transl Med. 2022 Mar 7;20(1):111
pubmed: 35255932
Int J Mol Sci. 2021 Apr 16;22(8):
pubmed: 33923593
Cell. 2009 Aug 7;138(3):416-20
pubmed: 19665961
Gut Microbes. 2020 Nov 1;11(6):1745-1757
pubmed: 32515657
Arch Microbiol. 2020 Oct;202(8):2147-2167
pubmed: 32524177
Nat Commun. 2019 Jan 18;10(1):310
pubmed: 30659181
Genomics Proteomics Bioinformatics. 2018 Feb;16(1):33-49
pubmed: 29474889
PLoS One. 2020 May 5;15(5):e0231789
pubmed: 32369505
Oncogene. 2022 Sep;41(36):4200-4210
pubmed: 35882981
Front Physiol. 2022 Jan 12;12:815842
pubmed: 35095572
World J Gastroenterol. 2019 May 7;25(17):2110-2121
pubmed: 31114137
Methods Mol Biol. 2020;2055:595-638
pubmed: 31502171
Dig Dis Sci. 2022 Jan;67(1):216-223
pubmed: 33723701
Autoimmun Rev. 2020 Sep;19(9):102621
pubmed: 32693029
EBioMedicine. 2022 Jul;81:104113
pubmed: 35753153
Front Microbiol. 2018 Sep 25;9:2247
pubmed: 30319571
Oncogene. 2022 Apr;41(15):2173-2186
pubmed: 35197571
Cell. 2015 Jan 29;160(3):447-60
pubmed: 25619688
Dtsch Arztebl Int. 2009 Dec;106(51-52):837-42
pubmed: 20062581
World J Gastroenterol. 2022 Aug 14;28(30):4053-4060
pubmed: 36157114
Am J Clin Nutr. 2004 Sep;80(3):737-41
pubmed: 15321816
Scand J Gastroenterol. 2019 Apr;54(4):391-396
pubmed: 30945954
PLoS One. 2009;4(3):e4903
pubmed: 19300508
Nutrients. 2019 Apr 24;11(4):
pubmed: 31022973
Enzyme Microb Technol. 2021 Sep;149:109836
pubmed: 34311881
Clin Transl Gastroenterol. 2020 Aug;11(8):e00199
pubmed: 32955191
Front Med (Lausanne). 2022 Jul 22;9:961703
pubmed: 35935766
Benef Microbes. 2014 Jun 1;5(2):129-36
pubmed: 24322880
Cell Mol Gastroenterol Hepatol. 2022;13(3):857-874
pubmed: 34506954
PLoS One. 2017 Dec 7;12(12):e0189257
pubmed: 29216305
Pediatr Obes. 2017 Aug;12 Suppl 1:3-17
pubmed: 28447406
Saudi J Gastroenterol. 2020 Mar-Apr;26(2):66-77
pubmed: 31898645
J Allergy Clin Immunol. 2020 Jan;145(1):16-27
pubmed: 31910984
Front Immunol. 2021 Feb 19;12:595762
pubmed: 33679739
World J Gastroenterol. 2022 May 14;28(18):1875-1901
pubmed: 35664966
Eur Rev Med Pharmacol Sci. 2019 Oct;23(20):9126-9133
pubmed: 31696504
Nat Rev Microbiol. 2011 Nov 21;10(1):66-78
pubmed: 22101918
Expert Rev Gastroenterol Hepatol. 2019 Oct;13(10):963-976
pubmed: 31603356
Eur J Clin Microbiol Infect Dis. 2017 Dec;36(12):2457-2468
pubmed: 28821976
Microbiome. 2020 Jun 30;8(1):103
pubmed: 32605663
Food Funct. 2015 Jan;6(1):257-64
pubmed: 25415771
Front Microbiol. 2019 Jul 10;10:1575
pubmed: 31354669
Int J Mol Sci. 2022 Oct 04;23(19):
pubmed: 36233048
Dig Dis. 2022;40(3):345-354
pubmed: 34315165
Gastroenterology. 2018 Aug;155(2):529-541.e5
pubmed: 29689266
J Surg Res. 2020 Jul;251:112-118
pubmed: 32135381
Crit Rev Food Sci Nutr. 2019;59(sup1):S130-S152
pubmed: 30580556
Gastroenterology. 2019 Jul;157(1):179-192.e2
pubmed: 30930024
Gut. 2021 Jul;70(7):1214-1240
pubmed: 33903147
Gut Microbes. 2019;10(2):149-158
pubmed: 30252582
Anaerobe. 2020 Apr;62:102100
pubmed: 31521732
Microorganisms. 2022 Oct 17;10(10):
pubmed: 36296324
Gut Microbes. 2022 Jan-Dec;14(1):1997296
pubmed: 34978524
Medicina (Kaunas). 2021 Aug 05;57(8):
pubmed: 34441008
J Clin Med. 2022 Mar 30;11(7):
pubmed: 35407527
Cancers (Basel). 2022 Sep 25;14(19):
pubmed: 36230584
BMC Gastroenterol. 2019 Jul 24;19(1):131
pubmed: 31340751