Pathogenesis and Current Treatment Strategies of Hepatocellular Carcinoma.
Barcelona Clinic Liver Cancer classification system (BCLC)
CTLA4
HCC
NAFLD
NASH
P53
PDL1
TERT
Tyrosine kinase inhibition (TKI)
atezolizumab
immune checkpoint inhibition
lenvatinib
non-alcoholic fatty liver disease
non-alcoholic steatohepatitis
pembrolizumab
trans-arterial chemoembolization (TACE)
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
09 Dec 2022
09 Dec 2022
Historique:
received:
31
10
2022
revised:
02
12
2022
accepted:
05
12
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
24
12
2022
Statut:
epublish
Résumé
Hepatocellular carcinoma (HCC) is the most frequent liver cancer with high lethality and low five-year survival rates leading to a substantial worldwide burden for healthcare systems. HCC initiation and progression are favored by different etiological risk factors including hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, non-/and alcoholic fatty liver disease (N/AFLD), and tobacco smoking. In molecular pathogenesis, endogenous alteration in genetics (
Identifiants
pubmed: 36551958
pii: biomedicines10123202
doi: 10.3390/biomedicines10123202
pmc: PMC9775527
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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