COVID-19 Still Surprising Us-A Rare Movement Disorder Induced by Infection.

COVID-19 reversible rhabdomyolysis stiff-person syndrome stiffness

Journal

Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646

Informations de publication

Date de publication:
17 Dec 2022
Historique:
received: 12 11 2022
revised: 27 11 2022
accepted: 15 12 2022
entrez: 23 12 2022
pubmed: 24 12 2022
medline: 24 12 2022
Statut: epublish

Résumé

Many neurological manifestations are part of COVID-19 infections, including movement disorders, but a clinical picture closely resembling stiff-person syndrome has not yet been described. We report a case of a stiff-person-like syndrome in the context of COVID-19 infection. A 79-year-old woman, with no prior history of diseases, presented global reversible stiffness associated with SARS-CoV-2 infection. We aim to shed light on several particularities regarding this clinical picture and its evolution in close relationship with the infectious disease progression, with full regression of symptoms and signs once the infectious process ceased. The impairment of speech and motility caused the wrong diagnosis of stroke in the Emergency Room. In addition, we would also like to emphasize the concomitant rhabdomyolysis, closely linked to the grade of muscle rigidity. We would like to raise awareness regarding this clinical setting and its association with SARS-COV-2 infection, to aid in its future recognition and management. To our knowledge, this is the first case of a stiff-person-like syndrome to be described in association with COVID-19 infection.

Sections du résumé

BACKGROUND BACKGROUND
Many neurological manifestations are part of COVID-19 infections, including movement disorders, but a clinical picture closely resembling stiff-person syndrome has not yet been described.
CASE PRESENTATION METHODS
We report a case of a stiff-person-like syndrome in the context of COVID-19 infection. A 79-year-old woman, with no prior history of diseases, presented global reversible stiffness associated with SARS-CoV-2 infection. We aim to shed light on several particularities regarding this clinical picture and its evolution in close relationship with the infectious disease progression, with full regression of symptoms and signs once the infectious process ceased. The impairment of speech and motility caused the wrong diagnosis of stroke in the Emergency Room. In addition, we would also like to emphasize the concomitant rhabdomyolysis, closely linked to the grade of muscle rigidity.
CONCLUSIONS CONCLUSIONS
We would like to raise awareness regarding this clinical setting and its association with SARS-COV-2 infection, to aid in its future recognition and management. To our knowledge, this is the first case of a stiff-person-like syndrome to be described in association with COVID-19 infection.

Identifiants

pubmed: 36552191
pii: brainsci12121733
doi: 10.3390/brainsci12121733
pmc: PMC9776586
pii:
doi:

Types de publication

Case Reports

Langues

eng

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Auteurs

Carmen Adella Sirbu (CA)

Department of Neurology, 'Dr. Carol Davila' Central Military Emergency University Hospital, 010242 Bucharest, Romania.

Diana Popescu (D)

Department of Neurology, 'Dr. Carol Davila' Central Military Emergency University Hospital, 010242 Bucharest, Romania.

Ion Stefan (I)

Department of Medico-Surgical and Prophylactic Disciplines, Titu Maiorescu University, 031593 Bucharest, Romania.
Department of Infectious Diseases, 'Dr. Carol Davila' Central Military Emergency University Hospital, 010242 Bucharest, Romania.

Constantin Stefani (C)

Department No. 5, University of Medicine and Pharmacy "Carol Davila", 050474 Bucharest, Romania.

Marian Mitrica (M)

Clinical Neurosciences Department, University of Medicine and Pharmacy "Carol Davila" Bucharest, 050474 Bucharest, Romania.

Daniela Anghel (D)

Department of Medico-Surgical and Prophylactic Disciplines, Titu Maiorescu University, 031593 Bucharest, Romania.
Department of Internal Medicine, Central Military Emergency University Hospital, 010242 Bucharest, Romania.

Classifications MeSH