Potential for Omega-3 Fatty Acids to Protect against the Adverse Effect of Phytosterols: Comparing Laboratory Outcomes in Adult Patients on Home Parenteral Nutrition Including Different Lipid Emulsions.
fish oil
inflammation
lipid emulsion
liver
parenteral nutrition
phytosterol
Journal
Biology
ISSN: 2079-7737
Titre abrégé: Biology (Basel)
Pays: Switzerland
ID NLM: 101587988
Informations de publication
Date de publication:
24 Nov 2022
24 Nov 2022
Historique:
received:
24
10
2022
revised:
19
11
2022
accepted:
21
11
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
24
12
2022
Statut:
epublish
Résumé
the effect on liver function markers and inflammation of the different content of phytosterols in lipid emulsions (LEs) used in the parenteral nutrition (PN) regimen of adult home PN (HPN) patients is not clear. plasma phytosterol and cytokine concentrations, fatty acid composition, liver function markers, and triglycerides were measured in 58 adult HPN patients receiving one of three different LEs (soybean oil-based: Intralipid; olive oil-based: ClinOleic; containing fish oil: SMOFLipid). patients receiving Intralipid had higher plasma campesterol and stigmasterol concentrations than those receiving ClinOleic or SMOFLipid. Plasma sterol concentrations were not different between patients receiving ClinOleic and SMOFLipid. Differences in plasma fatty acids reflected the fatty acid composition of the LEs. Markers of liver function did not differ among the three groups. Blood triglycerides were higher with ClinOleic than with Intralipid or SMOFLipid. Total bilirubin correlated positively with the plasma concentrations of two of the phytosterols, ALT correlated positively with one, AST with one, and GGT with three. liver function markers correlate with plasma plant sterol concentrations in adult HPN patients. Adult HPN patients receiving SMOFLipid are more likely to have liver function markers and triglycerides within the normal range than those receiving ClinOleic or Intralipid. The omega-3 fatty acids in SMOFLipid may act to mitigate the adverse effects of plant sterols on liver function.
Sections du résumé
BACKGROUND
BACKGROUND
the effect on liver function markers and inflammation of the different content of phytosterols in lipid emulsions (LEs) used in the parenteral nutrition (PN) regimen of adult home PN (HPN) patients is not clear.
METHODS
METHODS
plasma phytosterol and cytokine concentrations, fatty acid composition, liver function markers, and triglycerides were measured in 58 adult HPN patients receiving one of three different LEs (soybean oil-based: Intralipid; olive oil-based: ClinOleic; containing fish oil: SMOFLipid).
RESULTS
RESULTS
patients receiving Intralipid had higher plasma campesterol and stigmasterol concentrations than those receiving ClinOleic or SMOFLipid. Plasma sterol concentrations were not different between patients receiving ClinOleic and SMOFLipid. Differences in plasma fatty acids reflected the fatty acid composition of the LEs. Markers of liver function did not differ among the three groups. Blood triglycerides were higher with ClinOleic than with Intralipid or SMOFLipid. Total bilirubin correlated positively with the plasma concentrations of two of the phytosterols, ALT correlated positively with one, AST with one, and GGT with three.
CONCLUSIONS
CONCLUSIONS
liver function markers correlate with plasma plant sterol concentrations in adult HPN patients. Adult HPN patients receiving SMOFLipid are more likely to have liver function markers and triglycerides within the normal range than those receiving ClinOleic or Intralipid. The omega-3 fatty acids in SMOFLipid may act to mitigate the adverse effects of plant sterols on liver function.
Identifiants
pubmed: 36552209
pii: biology11121699
doi: 10.3390/biology11121699
pmc: PMC9774711
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Apr 15;957:116-22
pubmed: 24674990
Prostaglandins Leukot Essent Fatty Acids. 2013 Sep;89(4):153-8
pubmed: 23602846
Clin Nutr. 2018 Jun;37(3):765-783
pubmed: 28712532
Clin Nutr. 2016 Apr;35(2):247-307
pubmed: 26944585
J Pediatr. 2022 Feb;241:173-180.e1
pubmed: 34695449
BMJ. 2011 Mar 18;342:d1447
pubmed: 21421667
Proc Nutr Soc. 2018 Feb;77(1):52-72
pubmed: 29039280
Gastroenterology. 1993 Dec;105(6):1806-13
pubmed: 8253356
Semin Liver Dis. 2010 May;30(2):186-94
pubmed: 20422500
Clin Nutr. 2018 Feb;37(1):1-18
pubmed: 28935438
J Pediatr Surg. 2013 Mar;48(3):573-8
pubmed: 23480915
Nat Rev Endocrinol. 2019 Dec;15(12):689-700
pubmed: 31554932
Farm Hosp. 2018 May 01;42(3):116-119
pubmed: 29730982
Am J Physiol Gastrointest Liver Physiol. 2004 Apr;286(4):G528-37
pubmed: 14656710
JPEN J Parenter Enteral Nutr. 2015 Sep;39(1 Suppl):18S-32S
pubmed: 26177664
J Soc Gynecol Investig. 2005 Dec;12(8):593-8
pubmed: 16325749
Clin Nutr. 2019 Jun;38(3):1198-1205
pubmed: 29778510
Eur J Clin Nutr. 2016 Oct;70(10):1106-1115
pubmed: 27142348
J Vis Exp. 2014 Mar 13;(85):
pubmed: 24686562
JPEN J Parenter Enteral Nutr. 2017 Aug;41(6):1014-1022
pubmed: 26962062
Clin Nutr. 2021 Mar;40(3):1115-1122
pubmed: 32758383
Curr Opin Clin Nutr Metab Care. 2022 Jul 1;25(4):248-255
pubmed: 35762160
Clin Liver Dis. 2016 Feb;20(1):159-76
pubmed: 26593297
JPEN J Parenter Enteral Nutr. 2014 Jul;38(5):608-16
pubmed: 23757305
Proc Nutr Soc. 2020 Jun 22;:1-13
pubmed: 32624016
Am J Clin Nutr. 2016 Feb;103(2):629S-34S
pubmed: 26791189
J Pediatr Gastroenterol Nutr. 2012 Jun;54(6):797-802
pubmed: 22157927
Am J Clin Nutr. 2014 Oct;100(4):1085-94
pubmed: 25099547
Lipids. 2010 Jan;45(1):63-71
pubmed: 20049583
Clin Nutr. 2018 Dec;37(6 Pt B):2324-2336
pubmed: 30143306
Front Biosci (Elite Ed). 2013 Jan 01;5(1):87-96
pubmed: 23276972
Biochim Biophys Acta. 2015 Apr;1851(4):469-84
pubmed: 25149823
Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2160-4
pubmed: 8384714
Clin Nutr. 2021 Sep;40(9):5196-5220
pubmed: 34479179
J Pediatr. 2008 Feb;152(2):232-6
pubmed: 18206695
Nat Clin Pract Gastroenterol Hepatol. 2006 Oct;3(10):574-85
pubmed: 17008927
Pediatr Res. 2007 Sep;62(3):301-6
pubmed: 17622954
Essays Biochem. 2020 Sep 23;64(3):423-441
pubmed: 32808658
J Pediatr. 2013 Apr;162(4):793-798.e1
pubmed: 23164314
Pharmacol Res. 2005 Feb;51(2):85-94
pubmed: 15629253
PDA J Pharm Sci Technol. 2013 May-Jun;67(3):247-54
pubmed: 23752751
Int J Mol Sci. 2018 Apr 14;19(4):
pubmed: 29662003