Development of a Nanoparticle-Based Approach for the Blood-Brain Barrier Passage in a Murine Model of Amyotrophic Lateral Sclerosis.


Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
10 12 2022
Historique:
received: 07 11 2022
revised: 06 12 2022
accepted: 08 12 2022
entrez: 23 12 2022
pubmed: 24 12 2022
medline: 27 12 2022
Statut: epublish

Résumé

The development of nanoparticles (NPs) to enable the passage of drugs across blood-brain barrier (BBB) represents one of the main challenges in neuropharmacology. In recent years, NPs that are able to transport drugs and interact with brain endothelial cells have been tested. Here, we investigated whether the functionalization of avidin-nucleic-acid-nanoassembly (ANANAS) with apolipoprotein E (ApoE) would allow BBB passage in the SOD1

Identifiants

pubmed: 36552768
pii: cells11244003
doi: 10.3390/cells11244003
pmc: PMC9776960
pii:
doi:

Substances chimiques

Superoxide Dismutase-1 EC 1.15.1.1
Pharmaceutical Preparations 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Martina Bruna Violatto (MB)

Department of Biochemistry and Molecular Pharmacology, Istituto di Ricerche Farmacologiche "Mario Negri" IRCCS, 20133 Milan, Italy.

Laura Pasetto (L)

Department of Biochemistry and Molecular Pharmacology, Istituto di Ricerche Farmacologiche "Mario Negri" IRCCS, 20133 Milan, Italy.

Elisabetta Casarin (E)

Ananas Nanotech S.r.l., 35131 Padua, Italy.

Camilla Tondello (C)

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35122 Padua, Italy.
Pharmazentrum Frankfurt/ZAFES, Goethe University Hospital Frankfurt, 60596 Frankfurt am Main, Germany.

Elisa Schiavon (E)

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35122 Padua, Italy.

Laura Talamini (L)

Department of Biochemistry and Molecular Pharmacology, Istituto di Ricerche Farmacologiche "Mario Negri" IRCCS, 20133 Milan, Italy.

Gloria Marchini (G)

Department of Biochemistry and Molecular Pharmacology, Istituto di Ricerche Farmacologiche "Mario Negri" IRCCS, 20133 Milan, Italy.

Alfredo Cagnotto (A)

Department of Biochemistry and Molecular Pharmacology, Istituto di Ricerche Farmacologiche "Mario Negri" IRCCS, 20133 Milan, Italy.

Annalisa Morelli (A)

Department of Biochemistry and Molecular Pharmacology, Istituto di Ricerche Farmacologiche "Mario Negri" IRCCS, 20133 Milan, Italy.

Alessia Lanno (A)

Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche "Mario Negri" IRCCS, 20133 Milan, Italy.

Alice Passoni (A)

Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche "Mario Negri" IRCCS, 20133 Milan, Italy.

Paolo Bigini (P)

Department of Biochemistry and Molecular Pharmacology, Istituto di Ricerche Farmacologiche "Mario Negri" IRCCS, 20133 Milan, Italy.

Margherita Morpurgo (M)

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35122 Padua, Italy.

Valentina Bonetto (V)

Department of Biochemistry and Molecular Pharmacology, Istituto di Ricerche Farmacologiche "Mario Negri" IRCCS, 20133 Milan, Italy.

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Classifications MeSH