Disruption of Multiple Overlapping Functions Following Stepwise Inactivation of the Extended Myc Network.
ChREBP
DNA repair
Mga
Mnt
MondoA
Mxd
N-Myc
aging
c-Myc
senescence
telomerase
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
16 12 2022
16 12 2022
Historique:
received:
28
09
2022
revised:
13
12
2022
accepted:
14
12
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
27
12
2022
Statut:
epublish
Résumé
Myc, a member of the "Myc Network" of bHLH-ZIP transcription factors, supervises proliferation, metabolism, and translation. It also engages in crosstalk with the related "Mlx Network" to co-regulate overlapping genes and functions. We investigated the consequences of stepwise conditional inactivation of Myc and Mlx in primary and SV40 T-antigen-immortalized murine embryonic fibroblasts (MEFs).
Identifiants
pubmed: 36552851
pii: cells11244087
doi: 10.3390/cells11244087
pmc: PMC9777503
pii:
doi:
Substances chimiques
Tumor Suppressor Protein p53
0
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
0
Antigens, Viral, Tumor
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK120531
Pays : United States
Organisme : NIH HHS
ID : RO1 CA174713
Pays : United States
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