The Use of Psychotropic Medication in Pediatric Oncology for Acute Psychological and Psychiatric Problems: Balancing Risks and Benefits.

antidepressant mental health pediatric oncology psychotropic drugs

Journal

Children (Basel, Switzerland)
ISSN: 2227-9067
Titre abrégé: Children (Basel)
Pays: Switzerland
ID NLM: 101648936

Informations de publication

Date de publication:
30 Nov 2022
Historique:
received: 02 11 2022
revised: 24 11 2022
accepted: 28 11 2022
entrez: 23 12 2022
pubmed: 24 12 2022
medline: 24 12 2022
Statut: epublish

Résumé

Severe acute behavioral and emotional problems represent one of the most serious treatment-related adverse effects for children and adolescents who have cancer. The critical and severe nature of these symptoms often makes necessary the use of psychotropic drugs. A working group composed of experts in multiple disciplines had the task of creating an agreement regarding a management plan for severe acute behavioral and emotional problems (SABEPs) in children and adolescents treated for cancer. To obtain global information on the use of psychotropic drugs in pediatric oncology, the working group first developed and mailed a 15-item questionnaire to many Italian pediatric oncology centers. Overall, an evident lack of knowledge and education regarding the use of psychotropic medications for the treatment of SABEPs was found. Thus, by referring to an adapted version of the Delphi method of consensus and standard methods for the elaboration of clinical questions (PICOs), the working group elaborated evidence-based recommendations for psychotropic drugs in the pediatric oncology setting. Furthermore, based on a thorough multivariate analysis of needs and difficulties, a comprehensive management flow was developed to optimize therapeutic interventions, which allows more accurate and efficient matching of the acute needs of patients while guiding treatment options.

Identifiants

pubmed: 36553324
pii: children9121878
doi: 10.3390/children9121878
pmc: PMC9777172
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Références

Eur Neuropsychopharmacol. 2011 Aug;21(8):621-45
pubmed: 20702068
Pharmacol Ther. 2013 Apr;138(1):103-41
pubmed: 23333322
J Child Adolesc Psychopharmacol. 2007 Jun;17(3):371-7
pubmed: 17630871
Leukemia. 2000 Mar;14(3):369-73
pubmed: 10720128
Cancer Med. 2021 Aug;10(16):5653-5660
pubmed: 34309238
Cancers (Basel). 2020 Jun 11;12(6):
pubmed: 32545204
Dialogues Clin Neurosci. 2015 Sep;17(3):327-35
pubmed: 26487813
Integr Cancer Ther. 2022 Jan-Dec;21:15347354221105563
pubmed: 35726681
Trials. 2012 Jul 09;13:106
pubmed: 22776534
Psychopharmacology (Berl). 2021 May;238(5):1265-1278
pubmed: 31938879
Arch Dis Child. 2018 Jun;103(6):557-564
pubmed: 29490933
Clin Pharmacol Ther. 2021 Oct;110(4):952-965
pubmed: 34145575
Intensive Care Med. 2012 Jun;38(6):1025-31
pubmed: 22407142
J Clin Oncol. 2020 Mar 20;38(9):954-962
pubmed: 32023163
Eur Geriatr Med. 2021 Jun;12(3):585-596
pubmed: 33721264
Transl Psychiatry. 2022 Jun 10;12(1):244
pubmed: 35688817
J Okla State Med Assoc. 2018 Oct;111(8):776-783
pubmed: 31379392
Int Rev Psychiatry. 2014 Feb;26(1):63-73
pubmed: 24716501
Blood. 2011 Jun 2;117(22):5803-15
pubmed: 21398581
J Child Adolesc Psychopharmacol. 2020 Oct;30(8):486-494
pubmed: 32845729
Drugs. 2001;61(1):81-110
pubmed: 11217873
Aust Prescr. 2019 Oct;42(5):152-157
pubmed: 31631928
Eur Neuropsychopharmacol. 2015 May;25(5):703-12
pubmed: 25432076
World J Clin Pediatr. 2018 Feb 8;7(1):9-26
pubmed: 29456928
PLoS One. 2020 Mar 23;15(3):e0230194
pubmed: 32203535
Neuropsychiatr Dis Treat. 2017 Aug 09;13:2151-2165
pubmed: 28860772
Pediatrics. 2014 Mar;133(3):563-7
pubmed: 24567009
Tumori. 2021 Oct;107(5):370-375
pubmed: 33876662
Lancet Psychiatry. 2020 Jul;7(7):581-601
pubmed: 32563306
Health Psychol. 2020 May;39(5):381-390
pubmed: 31971403
Expert Rev Neurother. 2009 Jul;9(7):975-84
pubmed: 19589048
J Adolesc Young Adult Oncol. 2020 Apr;9(2):196-201
pubmed: 31747324
Adv Ther. 2019 Oct;36(Suppl 3):73-90
pubmed: 31399884
Expert Rev Anticancer Ther. 2011 Nov;11(11):1623-5
pubmed: 22050010
Pediatr Blood Cancer. 2006 Sep;47(3):339-42
pubmed: 16007589
Eur Neuropsychopharmacol. 2015 Oct;25(10):1513-31
pubmed: 26166453
Front Pharmacol. 2022 Apr 12;13:837692
pubmed: 35496268
Nervenarzt. 2020 May;91(5):391-397
pubmed: 32246170
Iran J Child Neurol. 2020 Winter;14(1):113-121
pubmed: 32021635
CA Cancer J Clin. 2015 Jul-Aug;65(4):300-14
pubmed: 26012508
Med Clin North Am. 2017 Nov;101(6):1099-1113
pubmed: 28992857
Curr Pharm Des. 2015;21(23):3280-97
pubmed: 26088115
BMC Health Serv Res. 2014 Nov 21;14:579
pubmed: 25413154
J Clin Psychopharmacol. 2016 Oct;36(5):500-7
pubmed: 27529772
Children (Basel). 2022 Jul 14;9(7):
pubmed: 35884035
Nat Rev Dis Primers. 2020 Nov 12;6(1):90
pubmed: 33184265
Int J Environ Res Public Health. 2020 Oct 15;17(20):
pubmed: 33076557
Eur J Pediatr. 2005 Sep;164(9):552-8
pubmed: 15912383
J Affect Disord. 2016 Apr;194:144-52
pubmed: 26826534
Mol Psychiatry. 2022 Jul 20;:
pubmed: 35854107
Neuropsychiatr Dis Treat. 2005 Dec;1(4):301-9
pubmed: 18568111
Adolesc Health Med Ther. 2016 Dec 23;8:11-29
pubmed: 28096698
Lancet. 2017 Jan 7;389(10064):14-16
pubmed: 27717609
Arch Dis Child. 2005 May;90(5):500-6
pubmed: 15851433
Psychiatr Serv. 2017 Jun 1;68(6):549-558
pubmed: 28093058
Crit Care Clin. 2009 Jul;25(3):593-614, x
pubmed: 19576533
Pharmacol Res Perspect. 2019 May 03;7(3):e00472
pubmed: 31065377
Neuropsychiatr Dis Treat. 2019 Apr 08;15:857-865
pubmed: 31118635
Front Oncol. 2021 Apr 22;11:627726
pubmed: 33968727
J Adolesc Health. 2017 Oct;61(4):409-423
pubmed: 28729145
Respir Res. 2022 Jul 28;23(1):192
pubmed: 35902927
Front Psychiatry. 2020 Jun 11;11:500
pubmed: 32595530
Swiss Med Wkly. 2022 Feb 04;152:w30124
pubmed: 35147399
Clin Pharmacol Ther. 2022 Dec;112(6):1243-1253
pubmed: 36069288
BMC Complement Med Ther. 2021 Mar 18;21(1):96
pubmed: 33736643
BMJ Open. 2019 Feb 20;9(2):e022839
pubmed: 30787076
Pediatr Blood Cancer. 2011 Sep;57(3):492-8
pubmed: 21560226
Dev Psychopathol. 2014 Feb;26(1):171-80
pubmed: 24444175
Cancer. 2010 Apr 1;116(7):1810-9
pubmed: 20187099
Lancet Oncol. 2022 Apr;23(4):e184-e196
pubmed: 35358467
Cancers (Basel). 2021 Sep 28;13(19):
pubmed: 34638332
Pharmacology. 2011;88(5-6):333-9
pubmed: 22123153
J Psychopharmacol. 2016 May;30(5):416-21
pubmed: 27098018
Ann Gen Hosp Psychiatry. 2004 Feb 12;3(1):2
pubmed: 14962351
Eur J Clin Pharmacol. 2019 Oct;75(10):1333-1346
pubmed: 31270564
Psychosomatics. 2011 Sep-Oct;52(5):417-23
pubmed: 21907059
Eur Neuropsychopharmacol. 2016 Mar;26(3):411-9
pubmed: 26970020
Arch Toxicol. 2020 Nov;94(11):3671-3722
pubmed: 33111191
Eur Neuropsychopharmacol. 2011 Aug;21(8):600-20
pubmed: 21550212
Pediatrics. 2021 Feb;147(2):
pubmed: 33495367
Health Serv Res. 2004 Apr;39(2):393-415
pubmed: 15032961
Psychiatry Clin Neurosci. 2011 Oct;65(6):549-60
pubmed: 22003987
Aust N Z J Psychiatry. 2020 Feb;54(2):127-129
pubmed: 31996029
Pharmacol Ther. 2022 Feb;230:107940
pubmed: 34174276
Psychiatry Clin Neurosci. 2003 Feb;57(1):75-81
pubmed: 12519458
P T. 2009 Aug;34(8):428-40
pubmed: 20140107
Child Adolesc Psychiatr Clin N Am. 2010 Apr;19(2):401-21, x-xi
pubmed: 20478507
Int J Cancer. 2018 Sep 15;143(6):1279-1286
pubmed: 29468674
Front Psychol. 2021 Apr 15;12:585534
pubmed: 33935849
Dialogues Clin Neurosci. 2002 Mar;4(1):7-20
pubmed: 22033824
Pediatrics. 2001 Mar;107(3):499-504
pubmed: 11230589
Lancet Psychiatry. 2017 May;4(5):409-418
pubmed: 28153641
Arch Dis Child. 2017 Jan;102(1):53-54
pubmed: 27535476
Neuropsychopharmacology. 2016 Jan;41(1):177-96
pubmed: 26334107
Children (Basel). 2018 Aug 28;5(9):
pubmed: 30154341
Future Oncol. 2017 Dec;13(29):2719-2731
pubmed: 29186986
J Psychosom Res. 2010 Apr;68(4):337-44
pubmed: 20307700
Arch Pediatr Adolesc Med. 2006 Aug;160(8):818-22
pubmed: 16894081
World J Psychiatry. 2015 Sep 22;5(3):273-85
pubmed: 26425442
Paediatr Drugs. 2014 Aug;16(4):267-74
pubmed: 24898718
Children (Basel). 2022 Mar 03;9(3):
pubmed: 35327719
Front Oncol. 2021 Jun 28;11:673581
pubmed: 34262863
JAMA Psychiatry. 2019 Aug 1;76(8):867-868
pubmed: 30994881
BMC Complement Med Ther. 2022 Apr 13;22(1):106
pubmed: 35418050
Oncology (Williston Park). 1992 Nov;6(11):45-50, 55; discussion 55-6
pubmed: 1445777
J Chronic Dis. 1984;37(6):465-80
pubmed: 6725500

Auteurs

Johanna M C Blom (JMC)

Department of Biomedical, Metabolic and Neural Sciences, School of Medicine, University of Modena, 41125 Modena, Italy.
Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, 41125 Modena, Italy.

Elena Barisone (E)

Pediatric Hematology and Oncology, Azienda Ospedaliero-Universitaria, Città Della Salute-OIRM, 102126 Turin, Italy.

Marina Bertolotti (M)

Pediatric Hematology and Oncology, Azienda Ospedaliero-Universitaria, Città Della Salute-OIRM, 102126 Turin, Italy.

Daniela Caprino (D)

Pediatric Hematology and Oncology, Institute Giannina Gaslini, 16147 Genoa, Italy.

Monica Cellini (M)

Department of Pediatric Oncology, Azienda Ospedaliero-Universitaria Policlinco di Modena, 41125 Modena, Italy.

Carlo Alfredo Clerici (CA)

Department of Hematology and Oncology, University of Milan, 20126 Milan, Italy.
Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milano, Italy.

Chiara Colliva (C)

Local Health Unit of Modena, District of Carpi, 41012 Carpi, Italy.

Cinzia Favara-Scacco (C)

A.O: U. Policlinico-San Marco Psychotherapy & LAD ONLUS, 95123 Catania, Italy.

Silvia Di Giuseppe (S)

Center for Pediatric Hemato-Oncology, Marche Polytechnic University, 61100 Ancona, Italy.

Momcilo Jankovic (M)

Paeditric Clinic, Universityof Milano-Bicocca, Fondazione MBBM, 20900 Monza, Italy.

Alessia Pancaldi (A)

Department of Pediatric Oncology, Azienda Ospedaliero-Universitaria Policlinco di Modena, 41125 Modena, Italy.

Luca Pani (L)

Department of Biomedical, Metabolic and Neural Sciences, School of Medicine, University of Modena, 41125 Modena, Italy.
Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Department of Psychiatry and Behavioral Sciences, University of Miami, Miami, FL 33136, USA.

Geraldina Poggi (G)

Scientific Institute, IRCCS E. Medea, Bosisio Parini, 23842 Lecco, Italy.

Veronica Rivi (V)

Department of Life Science, University of Modena and Reggio Emilia, 41125 Modena, Italy.

Fabio Tascedda (F)

Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Department of Life Science, University of Modena and Reggio Emilia, 41125 Modena, Italy.

Riccardo Torta (R)

Department of Neuroscience, University of Turin, 10124 Turin, Italy.

Dorella Scarponi (D)

Unità Operativa Pediatria Pession, IRSSC S. Orsola, 40138 Bologna, Italy.

Classifications MeSH