Retinal Photoreceptor Protection in an AMD-Related Mouse Model by Selective Sigma-1 or Sigma-2 Receptor Modulation.
AMD-related model
photoreceptor protection
retinal pigment epithelium
selective ligands
sigma-1 and sigma-2 receptors
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
16 12 2022
16 12 2022
Historique:
received:
03
11
2022
revised:
04
12
2022
accepted:
14
12
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
27
12
2022
Statut:
epublish
Résumé
The structurally and genetically distinct sigma-1 receptor (S1R) and sigma-2 receptor (S2R) comprise a unique class of drug binding sites. Their alleles are associated with human diseases involving neuronal systems, such as age-related macular degeneration (AMD) characterized by photoreceptor and retinal pigment epithelium (RPE) atrophy. Previous studies have suggested neuroprotective benefits for the brain and retina from pharmacological modulation of S1R and/or S2R. However, the effect of such modulation on AMD pathology remains underexplored. Here, we evaluated S1R- or S2R-selective modulation in an AMD-related model of
Identifiants
pubmed: 36553653
pii: genes13122386
doi: 10.3390/genes13122386
pmc: PMC9778362
pii:
doi:
Substances chimiques
Abca4 protein, mouse
0
ATP-Binding Cassette Transporters
0
Pentazocine
RP4A60D26L
sigma-2 receptor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NEI NIH HHS
ID : P30 EY016665
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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