Identification of Novel Artemisinin Hybrids Induce Apoptosis and Ferroptosis in MCF-7 Cells.

Humans MCF-7 Cells Molecular Structure Ferroptosis Antineoplastic Agents / pharmacology Drug Screening Assays, Antitumor Apoptosis Artemisinins / pharmacology Cell Proliferation Structure-Activity Relationship Cell Line, Tumor
1,3,4-oxadiazole antitumor apoptosis artemisinin ferroptosis

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
12 Dec 2022
Historique:
received: 23 09 2022
revised: 24 11 2022
accepted: 05 12 2022
entrez: 23 12 2022
pubmed: 24 12 2022
medline: 27 12 2022
Statut: epublish

Résumé

A series of novel 1,3,4-oxadiazole-artemisinin hybrids have been designed and synthesized. An MTT assay revealed that most of tested hybrids showed more enhanced anti-proliferative activities than artemisinin, among which A8 had the superior potency with IC

Identifiants

DOI: 10.3390/ijms232415768 PMID: 36555409 PMC: PMC9779727
pubmed: 36555409
pii: ijms232415768
doi: 10.3390/ijms232415768
pmc: PMC9779727
pii:
doi:

Substances chimiques

Antineoplastic Agents 0
artemisinin 9RMU91N5K2
Artemisinins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : National Natural Science Foundation of China
ID : 22177079
Organisme : National Natural Science Foundation of China
ID : 81473087

Références

Bioorg Chem. 2021 Jan;106:104496
pubmed: 33288320
Expert Opin Ther Pat. 2022 Sep;32(9):969-1001
pubmed: 35993146
Bioorg Med Chem Lett. 2021 May 1;39:127912
pubmed: 33691167
Nat Med. 2004 Aug;10(8):789-99
pubmed: 15286780
Nat Rev Mol Cell Biol. 2021 Apr;22(4):266-282
pubmed: 33495651
Cell Res. 2021 Feb;31(2):107-125
pubmed: 33268902
Eur J Med Chem. 2016 Nov 29;124:500-536
pubmed: 27598238
Oxid Med Cell Longev. 2022 Jan 4;2022:1458143
pubmed: 35028002
J Org Chem. 2013 Jan 18;78(2):438-44
pubmed: 23215154
Biomed Pharmacother. 2022 Mar;147:112658
pubmed: 35066300
Eur J Med Chem. 2021 Apr 5;215:113295
pubmed: 33636536
Curr Top Med Chem. 2022;22(7):578-599
pubmed: 35114924
RSC Chem Biol. 2020 Dec 8;2(1):151-165
pubmed: 34458778
Front Cell Infect Microbiol. 2018 Jul 26;8:256
pubmed: 30094226
J Enzyme Inhib Med Chem. 2022 Dec;37(1):2304-2319
pubmed: 36000176
Blood Adv. 2021 Feb 9;5(3):711-724
pubmed: 33560385
Bioorg Chem. 2021 Jun;111:104903
pubmed: 33894433
Mol Biol Rep. 2020 Aug;47(8):6321-6336
pubmed: 32710388
Eur J Med Chem. 2021 Feb 5;211:113000
pubmed: 33261896
Nat Prod Rep. 2022 Jun 22;39(6):1122-1171
pubmed: 35201245
CA Cancer J Clin. 2021 Jan;71(1):7-33
pubmed: 33433946
Nat Rev Clin Oncol. 2022 May;19(5):306-327
pubmed: 35105976
Molecules. 2022 Jan 06;27(2):
pubmed: 35056662
Eur J Med Chem. 2021 Dec 5;225:113754
pubmed: 34399390
Arch Pharm (Weinheim). 2022 Sep;355(9):e2200123
pubmed: 35575467

Auteurs

Ye Zhong (Y)

Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.

Zhi-Ning Li (ZN)

Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.

Xin-Yue Jiang (XY)

Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.

Xing Tian (X)

Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.

Ming-Hui Deng (MH)

Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.

Mao-Sheng Cheng (MS)

Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.

Hua-Li Yang (HL)

Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.

Yang Liu (Y)

Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
ORCID: 0000-0002-9284-1944

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Identification of Novel Artemisinin Hybrids...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Cellules MCF-7 › Identification of Novel Artemisinin Hybrids...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Identification of Novel Artemisinin Hybrids...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Ferroptose › Identification of Novel Artemisinin Hybrids...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Identification of Novel Artemisinin Hybrids...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de criblage d'agents antitumoraux › Identification of Novel Artemisinin Hybrids...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Identification of Novel Artemisinin Hybrids...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Sesquiterpènes › Artémisinines › Identification of Novel Artemisinin Hybrids...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Identification of Novel Artemisinin Hybrids...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Identification of Novel Artemisinin Hybrids...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Identification of Novel Artemisinin Hybrids...