Current Insights on the Use of Insulin and the Potential Use of Insulin Mimetics in Targeting Insulin Signalling in Alzheimer's Disease.
Alzheimer’s disease
biomarkers
insulin mimetics
insulin signalling
neurodegeneration
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
13 Dec 2022
13 Dec 2022
Historique:
received:
21
09
2022
revised:
10
12
2022
accepted:
11
12
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
27
12
2022
Statut:
epublish
Résumé
Alzheimer's disease (AD) and type 2 diabetes (T2D) are chronic diseases that share several pathological mechanisms, including insulin resistance and impaired insulin signalling. Their shared features have prompted the evaluation of the drugs used to manage diabetes for the treatment of AD. Insulin delivery itself has been utilized, with promising effects, in improving cognition and reducing AD related neuropathology. The most recent clinical trial involving intranasal insulin reported no slowing of cognitive decline; however, several factors may have impacted the trial outcomes. Long-acting and rapid-acting insulin analogues have also been evaluated within the context of AD with a lack of consistent outcomes. This narrative review provided insight into how targeting insulin signalling in the brain has potential as a therapeutic target for AD and provided a detailed update on the efficacy of insulin, its analogues and the outcomes of human clinical trials. We also discussed the current evidence that warrants the further investigation of the use of the mimetics of insulin for AD. These small molecules may provide a modifiable alternative to insulin, aiding in developing drugs that selectively target insulin signalling in the brain with the aim to attenuate cognitive dysfunction and AD pathologies.
Identifiants
pubmed: 36555450
pii: ijms232415811
doi: 10.3390/ijms232415811
pmc: PMC9779379
pii:
doi:
Substances chimiques
Insulin
0
Insulin, Regular, Human
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Front Mol Neurosci. 2020 Mar 10;13:21
pubmed: 32210760
Expert Opin Investig Drugs. 2003 Feb;12(2):223-33
pubmed: 12556216
Arch Neurol. 2012 Jan;69(1):29-38
pubmed: 21911655
Neurology. 2019 Feb 19;92(8):e823-e830
pubmed: 30674592
Science. 1999 May 7;284(5416):974-7
pubmed: 10320380
J Neurosci. 2016 Nov 16;36(46):11704-11715
pubmed: 27852778
Mediators Inflamm. 2015;2015:105828
pubmed: 26693205
Int J Mol Sci. 2020 Mar 03;21(5):
pubmed: 32138327
Biol Rev Camb Philos Soc. 2021 Oct;96(5):2209-2228
pubmed: 34159699
J Clin Endocrinol Metab. 1995 Nov;80(11):3311-20
pubmed: 7593444
Int J Mol Sci. 2021 Jun 16;22(12):
pubmed: 34208561
Front Aging Neurosci. 2021 Nov 12;13:774477
pubmed: 34867302
Neuron. 2015 Jan 21;85(2):296-302
pubmed: 25611508
Alzheimers Res Ther. 2021 Jan 5;13(1):9
pubmed: 33402193
Life Sci. 2017 Mar 15;173:1-10
pubmed: 27693383
Neurosci Lett. 2020 Jan 1;714:134567
pubmed: 31629033
Alzheimers Dement (Amst). 2021 Jul 28;13(1):e12220
pubmed: 34337133
Neurosci Biobehav Rev. 2021 Dec;131:792-805
pubmed: 34634357
Front Neurosci. 2019 Jun 18;13:629
pubmed: 31275108
Chin Med J (Engl). 2008 Nov 5;121(21):2124-8
pubmed: 19080170
J Clin Invest. 1995 Jun;95(6):2501-9
pubmed: 7769096
J Pediatr Gastroenterol Nutr. 2018 Jun;66 Suppl 3:S46-S49
pubmed: 29762377
Int J Mol Sci. 2020 Mar 04;21(5):
pubmed: 32143329
J Clin Invest. 1991 Apr;87(4):1286-94
pubmed: 1707061
CNS Drugs. 2019 May;33(5):457-480
pubmed: 30900203
Sci Rep. 2022 Jan 25;12(1):1346
pubmed: 35079029
CNS Drugs. 2014 Dec;28(12):1185-9
pubmed: 25373630
Neurobiol Aging. 2017 Oct;58:1-13
pubmed: 28688899
Prog Biophys Mol Biol. 2022 Nov;175:49-62
pubmed: 36108780
Int J Mol Sci. 2022 Aug 11;23(16):
pubmed: 36012242
Annu Rev Biochem. 2017 Jun 20;86:27-68
pubmed: 28498720
Neurotox Res. 2018 May;33(4):716-724
pubmed: 28929339
Drug Discov Today. 2013 Aug;18(15-16):748-55
pubmed: 23603635
J Physiol Pharmacol. 2019 Dec;70(6):
pubmed: 32084643
Curr Alzheimer Res. 2020;17(14):1294-1301
pubmed: 33602093
Brain Behav Immun. 2018 May;70:423-434
pubmed: 29604345
Int J Mol Sci. 2021 Jan 16;22(2):
pubmed: 33467075
J Intern Med. 2016 Nov;280(5):430-442
pubmed: 27739227
Nat Rev Mol Cell Biol. 2018 Jan;19(1):31-44
pubmed: 28974775
J Alzheimers Dis. 2019;69(2):489-498
pubmed: 30958348
Neural Regen Res. 2022 Mar;17(3):618-624
pubmed: 34380902
Drug Discov Today. 2017 Jul;22(7):1092-1102
pubmed: 28476537
Inflammation. 2022 Oct;45(5):2016-2026
pubmed: 35460012
Neurobiol Aging. 2006 Feb;27(2):190-8
pubmed: 16399206
Diabetes Care. 2020 May;43(5):1085-1093
pubmed: 32139381
J Inorg Biochem. 2009 Apr;103(4):554-8
pubmed: 19162329
Cell Metab. 2021 Apr 6;33(4):740-747
pubmed: 33826916
Neurotox Res. 2020 Mar;37(3):508-524
pubmed: 31782098
J Biol Chem. 2000 Nov 24;275(47):36590-5
pubmed: 10967116
Diabetes Res Clin Pract. 2018 Jun;140:339-346
pubmed: 29588170
Neuropharmacology. 2018 Jul 1;136(Pt B):251-259
pubmed: 29402504
Lancet Neurol. 2020 Sep;19(9):758-766
pubmed: 32730766
Neurol Sci. 2016 Jan;37(1):9-16
pubmed: 26442674
J Alzheimers Dis Rep. 2022 Jun 22;6(1):349-357
pubmed: 35891636
Neuropsychopharmacology. 2007 Jan;32(1):239-43
pubmed: 16936707
Cells. 2021 May 11;10(5):
pubmed: 34064687
Diabetologia. 2017 Sep;60(9):1577-1585
pubmed: 28776086
Diabetes. 2012 Dec;61(12):3126-38
pubmed: 22829447
Curr Alzheimer Res. 2019;16(8):741-752
pubmed: 31518224
Front Aging Neurosci. 2018 Jul 27;10:227
pubmed: 30100873
J Neurosci Res. 2020 Nov;98(11):2357-2369
pubmed: 32737929
BMJ Open. 2019 Jul 30;9(7):e024954
pubmed: 31366635
J Prev Alzheimers Dis. 2021;8(3):240-248
pubmed: 34101779
Biosci Rep. 2018 Jan 10;38(1):
pubmed: 29222348
J Am Heart Assoc. 2018 Sep 18;7(18):e009379
pubmed: 30371206
J Ethnopharmacol. 2009 Jun 22;123(2):280-7
pubmed: 19429373
Ageing Res Rev. 2021 Sep;70:101395
pubmed: 34153553
Pharmacology. 2016;98(5-6):242-250
pubmed: 27449930
BMC Complement Altern Med. 2017 Apr 13;17(1):214
pubmed: 28407770
Behav Brain Res. 2019 Sep 16;370:111932
pubmed: 31082410
Ann Neurol. 2015 Aug;78(2):284-94
pubmed: 25974006
J Biol Chem. 2002 Nov 15;277(46):43565-71
pubmed: 12213804
Neuroendocrinology. 2001 Oct;74(4):270-80
pubmed: 11598383
PLoS One. 2019 Feb 15;14(2):e0212293
pubmed: 30768625
Nat Commun. 2019 Jan 24;10(1):409
pubmed: 30679421
Sci Rep. 2017 Aug 29;7(1):9766
pubmed: 28852028
J Alzheimers Dis. 2015;45(4):1269-70
pubmed: 25869922
ACS Omega. 2018 Feb 28;3(2):2452-2462
pubmed: 30023834
J Alzheimers Dis. 2016;51(2):501-14
pubmed: 26890736
Brain Res Bull. 2019 Jan;144:21-27
pubmed: 30395886
J Alzheimers Dis. 2017;57(4):1325-1334
pubmed: 28372335
Free Radic Biol Med. 1999 Aug;27(3-4):309-14
pubmed: 10468203
Complement Med Res. 2021;28(3):226-233
pubmed: 33302270
Diabetologia. 2012 Oct;55(10):2565-2582
pubmed: 22869320
FASEB J. 2017 Dec;31(12):5409-5418
pubmed: 28808140
J Biol Chem. 2012 Mar 16;287(12):9299-310
pubmed: 22275369
Bioorg Chem. 2022 Apr;121:105626
pubmed: 35255350
Arch Iran Med. 2013 Jul;16(7):408-11
pubmed: 23808778
Alzheimers Res Ther. 2022 Apr 20;14(1):56
pubmed: 35443732
Sci Rep. 2016 Feb 16;6:21186
pubmed: 26879001
J Food Biochem. 2020 Nov;44(11):e13477
pubmed: 32984986
FASEB J. 2008 Jan;22(1):246-60
pubmed: 17720802
Biochim Biophys Acta Mol Cell Res. 2020 May;1867(5):118664
pubmed: 32006534
Mol Neurodegener. 2019 Jan 11;14(1):2
pubmed: 30634998
Int J Mol Sci. 2022 May 06;23(9):
pubmed: 35563589
Neurology. 1998 Jan;50(1):164-8
pubmed: 9443474
J Clin Invest. 2012 Apr;122(4):1316-38
pubmed: 22476197
Endocrinol Diabetes Metab. 2020 Dec 07;4(2):e00212
pubmed: 33855214
3 Biotech. 2020 Aug;10(8):359
pubmed: 32832321
Cochrane Database Syst Rev. 2020 Nov 9;11:CD005613
pubmed: 33166419
Endocrinology. 2004 Nov;145(11):5259-68
pubmed: 15297448
Phytomedicine. 2022 Jul;101:154099
pubmed: 35489323
J Pathol. 2018 May;245(1):85-100
pubmed: 29435980
Lancet Diabetes Endocrinol. 2019 May;7(5):385-396
pubmed: 30926258
Mol Neurobiol. 2018 May;55(5):4030-4050
pubmed: 28573460
Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt B):77-83
pubmed: 28583443
Brain. 2005 Jun;128(Pt 6):1442-53
pubmed: 15817521
Int J Biol Sci. 2018 Aug 6;14(11):1483-1496
pubmed: 30263000
J Alzheimers Dis. 2019;67(3):795-819
pubmed: 30776012
Curr Alzheimer Res. 2021;18(7):546-557
pubmed: 34587885
Pharmacol Rep. 2019 Aug;71(4):614-623
pubmed: 31176103
J Inorg Biochem. 2020 Jul;208:111094
pubmed: 32438270
NPJ Regen Med. 2017 Mar 3;2:4
pubmed: 29302341
FASEB J. 2013 Jan;27(1):199-207
pubmed: 23073831
Biomed Pharmacother. 2020 Jan;121:109670
pubmed: 31810131
Drugs Aging. 2021 May;38(5):407-415
pubmed: 33719017
BMJ. 1997 Oct 25;315(7115):1045-9
pubmed: 9366728
J Endocrinol. 2016 Sep;230(3):291-307
pubmed: 27411561
Sci Rep. 2017 Nov 8;7(1):15086
pubmed: 29118444
Lancet. 2017 Jun 3;389(10085):2239-2251
pubmed: 28190580
Neuropharmacology. 2014 Nov;86:241-58
pubmed: 25107586
J Neurosci Res. 2008 Nov 15;86(15):3265-74
pubmed: 18627032
Aging Cell. 2021 Feb;20(2):e13277
pubmed: 33443781
Food Chem Toxicol. 2016 Sep;95:137-41
pubmed: 27417449
Cell Cycle. 2010 Feb 1;9(3):487-97
pubmed: 20081374
J Pathol. 2011 Sep;225(1):54-62
pubmed: 21598254
J Neural Transm (Vienna). 2015 Apr;122(4):593-606
pubmed: 25113171
Diabetologia. 2019 Mar;62(3):448-458
pubmed: 30547230
Lancet Neurol. 2021 Jul;20(7):537-547
pubmed: 34146512
Molecules. 2018 Oct 11;23(10):
pubmed: 30314325
J Alzheimers Dis. 2019;71(4):1361-1373
pubmed: 31561374
Behav Brain Res. 2013 Mar 15;241:105-11
pubmed: 23238038
Diabetes Care. 2014 Feb;37(2):507-15
pubmed: 24103900
BMJ Open Diabetes Res Care. 2020 Nov;8(2):
pubmed: 33203727
Lancet. 2020 Aug 8;396(10248):413-446
pubmed: 32738937
Am J Alzheimers Dis Other Demen. 2020 Jan-Dec;35:1533317519899546
pubmed: 32162525
Elife. 2022 May 24;11:
pubmed: 35608247
J Am Geriatr Soc. 2009 Jan;57(1):177-9
pubmed: 19170800
Metallomics. 2021 Jul 2;13(7):
pubmed: 34124763
Front Neurosci. 2021 Apr 23;15:653651
pubmed: 33967682
Eur J Nutr. 2021 Sep;60(6):3071-3083
pubmed: 33486572
JAMA Neurol. 2020 Sep 1;77(9):1099-1109
pubmed: 32568367
Protein Cell. 2021 Oct;12(10):769-787
pubmed: 34291435
Nat Med. 2021 Sep;27(9):1592-1599
pubmed: 34446931
Endocr Rev. 2021 Jan 28;42(1):77-96
pubmed: 32897388
BMJ Open Diabetes Res Care. 2020 Jun;8(1):
pubmed: 32546549
N Engl J Med. 2019 Aug 15;381(7):637-646
pubmed: 31034184
Alzheimers Dement. 2022 Apr;18(4):700-789
pubmed: 35289055
Am J Ther. 2020 Jan/Feb;27(1):e42-e51
pubmed: 31876563
BMC Med. 2020 Aug 21;18(1):224
pubmed: 32819363
Curr Pharm Des. 2020;26(43):5637-5649
pubmed: 32912117
Neuropharmacology. 2020 Jan 1;162:107813
pubmed: 31628935
PLoS One. 2013 Jul 17;8(7):e69830
pubmed: 23875003
Geriatr Gerontol Int. 2019 Aug;19(8):755-761
pubmed: 31119857
Endocrinology. 2013 Jan;154(1):375-87
pubmed: 23239816
Histol Histopathol. 2022 May;37(5):431-439
pubmed: 35040114
Amyloid. 2016 Sep;23(3):139-147
pubmed: 27159045
Front Aging Neurosci. 2021 Dec 16;13:741923
pubmed: 34975451
Int J Mol Sci. 2020 Mar 05;21(5):
pubmed: 32150819
Oxid Med Cell Longev. 2020 Apr 19;2020:2315106
pubmed: 32377293
Pharmaceutics. 2019 Mar 13;11(3):
pubmed: 30871237
Curr Med Chem. 2016;23(25):2874-2891
pubmed: 26997154
Alzheimers Dement. 2020 Dec;16(12):1663-1673
pubmed: 32803865
Cell. 2017 Apr 20;169(3):381-405
pubmed: 28431241
Diabetes Care. 2016 Feb;39(2):300-7
pubmed: 26681727
J Med Chem. 2000 Sep 21;43(19):3487-94
pubmed: 11000003
Clin Anat. 2021 Jul;34(5):766-773
pubmed: 33580904
Diabetes Metab J. 2022 Sep;46(5):815-816
pubmed: 36193730
Neuroendocrinology. 1999 Aug;70(2):146-52
pubmed: 10461029
Molecules. 2020 Nov 07;25(21):
pubmed: 33171799
Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):499-508
pubmed: 27771511
Diabetologia. 1988 Mar;31(3):158-61
pubmed: 3286343
Trials. 2019 Apr 3;20(1):191
pubmed: 30944040
J Cell Biol. 2018 Jul 2;217(7):2273-2289
pubmed: 29622564
Sci Rep. 2017 Jun 1;7(1):2661
pubmed: 28572610
Metallomics. 2020 Apr 1;12(4):474-490
pubmed: 31970356
Diabetes Care. 2018 Dec;41(12):2535-2543
pubmed: 30327356
Diabetes Care. 2020 Nov;43(11):2691-2701
pubmed: 32967921
Diabetes Metab Syndr. 2019 May - Jun;13(3):2126-2141
pubmed: 31235147
Aging Cell. 2016 Oct;15(5):893-902
pubmed: 27457264
Med Sci Monit. 2021 Sep 02;27:e933084
pubmed: 34471085
Sci Rep. 2019 Feb 22;9(1):2621
pubmed: 30796294
Endocrinology. 1989 Nov;125(5):2510-6
pubmed: 2676485
J Alzheimers Dis. 2017;59(2):421-432
pubmed: 28269785
PLoS One. 2020 Oct 2;15(10):e0240044
pubmed: 33007022
CNS Neurosci Ther. 2018 Sep;24(9):763-774
pubmed: 29691988
J Clin Endocrinol Metab. 2008 Jul;93(7):2559-65
pubmed: 18397984
ACS Chem Neurosci. 2021 Jun 2;12(11):1894-1904
pubmed: 33983710
Pflugers Arch. 2020 Sep;472(9):1299-1343
pubmed: 32789766
J Alzheimers Dis. 2013;35(4):789-97
pubmed: 23507773
Diabetes Res Clin Pract. 2020 Sep;167:108356
pubmed: 32745695
Biotechnol Prog. 2014 Mar-Apr;30(2):488-95
pubmed: 24376182
Alzheimers Dement (N Y). 2016 Dec 20;3(1):92-106
pubmed: 29067321
J Alzheimers Dis. 2008 Apr;13(3):323-31
pubmed: 18430999
Oxid Med Cell Longev. 2021 Dec 15;2021:2074610
pubmed: 34956436
Neurobiol Aging. 2012 Dec;33(12):2903-19
pubmed: 22459600
J Neurosci. 2016 Oct 12;36(41):10683-10695
pubmed: 27733618
Nat Med. 2002 Feb;8(2):179-83
pubmed: 11821903
Cells. 2021 May 18;10(5):
pubmed: 34069890
Int J Mol Sci. 2018 Oct 24;19(11):
pubmed: 30355995
Nat Rev Neurol. 2018 Mar;14(3):168-181
pubmed: 29377010
Psychoneuroendocrinology. 2004 Nov;29(10):1326-34
pubmed: 15288712
Biochemistry. 2007 Feb 27;46(8):2146-55
pubmed: 17274632
Biochem J. 2002 Oct 1;367(Pt 1):301-6
pubmed: 12036431
J Alzheimers Dis. 2019;70(3):793-810
pubmed: 31256135
Sci Rep. 2017 Apr 06;7:45971
pubmed: 28382978
J Theor Biol. 2020 Dec 21;507:110454
pubmed: 32822700
PLoS One. 2012;7(7):e41344
pubmed: 22848469
Curr Diabetes Rev. 2020;16(5):442-449
pubmed: 31657690
J Neuroendocrinol. 2021 Apr;33(4):e12934
pubmed: 33506526
J Neurochem. 2001 Sep;78(5):1135-45
pubmed: 11553687
Front Pharmacol. 2021 Jul 19;12:640758
pubmed: 34349640
Neuromolecular Med. 2013 Mar;15(1):102-14
pubmed: 23011726
Int J Mol Sci. 2020 Jun 30;21(13):
pubmed: 32629793
J Inorg Biochem. 2006 Dec;100(12):1925-35
pubmed: 17055061
Mol Neurobiol. 2019 Nov;56(11):7267-7283
pubmed: 31016475
Curr Diab Rep. 2019 Aug 9;19(9):81
pubmed: 31399863
Am J Physiol Cell Physiol. 2019 Sep 1;317(3):C420-C433
pubmed: 31216193
Neuropharmacology. 2022 Apr 1;207:108966
pubmed: 35077762
Exp Neurol. 2014 Nov;261:610-9
pubmed: 24918340
J Endocrinol. 2014 Jun;221(3):R105-20
pubmed: 24667247
Peptides. 2018 Feb;100:101-107
pubmed: 29412810
J Cereb Blood Flow Metab. 2015 Mar;35(3):371-81
pubmed: 25492117
Drug Deliv Transl Res. 2022 Apr;12(4):735-757
pubmed: 33491126
Biochim Biophys Acta. 2016 Apr;1862(4):511-517
pubmed: 26769360
Sleep Med Rev. 2018 Aug;40:4-16
pubmed: 28890168
Biomedicines. 2022 Jul 19;10(7):
pubmed: 35885050