The Modular Architecture of Metallothioneins Facilitates Domain Rearrangements and Contributes to Their Evolvability in Metal-Accumulating Mollusks.
Cephalopoda and Caudofoveata MTs
de novo domains
domain repeat proteins
protein modularity
sORFs and lncRNAs
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
13 Dec 2022
13 Dec 2022
Historique:
received:
10
11
2022
revised:
05
12
2022
accepted:
10
12
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
27
12
2022
Statut:
epublish
Résumé
Protein domains are independent structural and functional modules that can rearrange to create new proteins. While the evolution of multidomain proteins through the shuffling of different preexisting domains has been well documented, the evolution of domain repeat proteins and the origin of new domains are less understood. Metallothioneins (MTs) provide a good case study considering that they consist of metal-binding domain repeats, some of them with a likely de novo origin. In mollusks, for instance, most MTs are bidomain proteins that arose by lineage-specific rearrangements between six putative domains: α, β1, β2, β3, γ and δ. Some domains have been characterized in bivalves and gastropods, but nothing is known about the MTs and their domains of other Mollusca classes. To fill this gap, we investigated the metal-binding features of NpoMT1 of
Identifiants
pubmed: 36555472
pii: ijms232415824
doi: 10.3390/ijms232415824
pmc: PMC9781358
pii:
doi:
Substances chimiques
Metals
0
Metallothionein
9038-94-2
Cadmium
00BH33GNGH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministerio de Ciencia e Innovación
ID : PID2021-123258NB-I00
Organisme : Ministerio de Ciencia e Innovación
ID : BIO2015-67358-C2-2-P
Organisme : Government of Catalonia
ID : 2017SGR-1665
Organisme : Government of Catalonia
ID : 2017SGR-864
Organisme : FWF Austrian Science Fund
ID : DACH grant No I 3032-B21
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