Solubility Enhancement of Dihydroquercetin via "Green" Phase Modification.
antioxidant
dihydroquercetin
flavonoid
lyophilization
phase modification
solubility
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 Dec 2022
15 Dec 2022
Historique:
received:
21
10
2022
revised:
29
11
2022
accepted:
13
12
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
27
12
2022
Statut:
epublish
Résumé
Dihydroquercetin (DHQ) is a promising antioxidant for medical applications. The poor water solubility of this flavanonol at ambient conditions inhibits its implementation in clinical practice as an injectable dosage form. Thus, increasing water solubility is a critical step toward solving this problem. Herein we attempted to deal with this problem via DHQ phase modification while at the same time adhering to the principles of green chemistry as much as possible. Lyophilization is an appropriate method to achieve phase modification in an environment-friendly way. This method was employed to generate new phase modifications of DHQ that were then characterized. Mixtures of water with ethanol or acetonitrile were used as solvents for the preparation of the lyophilizates, DHQ
Identifiants
pubmed: 36555607
pii: ijms232415965
doi: 10.3390/ijms232415965
pmc: PMC9785474
pii:
doi:
Substances chimiques
taxifolin
9SOB9E3987
Solvents
0
Quercetin
9IKM0I5T1E
Water
059QF0KO0R
Antioxidants
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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