Comparison of Bioluminescent Substrates in Natural Infection Models of Neglected Parasitic Diseases.
AkaLumine-HCl
CycLuc1
D-luciferin
Leishmania
Trypanosoma
bioluminescence
reporter gene technology
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 Dec 2022
16 Dec 2022
Historique:
received:
17
11
2022
revised:
08
12
2022
accepted:
09
12
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
27
12
2022
Statut:
epublish
Résumé
The application of in vivo bioluminescent imaging in infectious disease research has significantly increased over the past years. The detection of transgenic parasites expressing wildtype firefly luciferase is however hampered by a relatively low and heterogeneous tissue penetrating capacity of emitted light. Solutions are sought by using codon-optimized red-shifted luciferases that yield higher expression levels and produce relatively more red or near-infrared light, or by using modified bioluminescent substrates with enhanced cell permeability and improved luminogenic or pharmacokinetic properties. In this study, the in vitro and in vivo efficacy of two modified bioluminescent substrates, CycLuc1 and AkaLumine-HCl, were compared with that of D-luciferin as a gold standard. Comparisons were made in experimental and insect-transmitted animal models of leishmaniasis (caused by intracellular
Identifiants
pubmed: 36555716
pii: ijms232416074
doi: 10.3390/ijms232416074
pmc: PMC9781651
pii:
doi:
Substances chimiques
Luciferases, Firefly
EC 1.13.12.7
Luciferases
EC 1.13.12.-
Luciferins
0
Firefly Luciferin
5TBB02N29K
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Research Foundation - Flanders
ID : 1501219N, G065421N
Organisme : University of Antwerp
ID : TT-ZAPBOF 33049, TOP-BOF 35017
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