Calcium Signalling in Heart and Vessels: Role of Calmodulin and Downstream Calmodulin-Dependent Protein Kinases.
calcium calmodulin dependent protein kinases
calcium signalling
calmodulin
cardiovascular disease
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 Dec 2022
17 Dec 2022
Historique:
received:
09
10
2022
revised:
11
12
2022
accepted:
13
12
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
27
12
2022
Statut:
epublish
Résumé
Cardiovascular disease is the major cause of death worldwide. The success of medication and other preventive measures introduced in the last century have not yet halted the epidemic of cardiovascular disease. Although the molecular mechanisms of the pathophysiology of the heart and vessels have been extensively studied, the burden of ischemic cardiovascular conditions has risen to become a top cause of morbidity and mortality. Calcium has important functions in the cardiovascular system. Calcium is involved in the mechanism of excitation-contraction coupling that regulates numerous events, ranging from the production of action potentials to the contraction of cardiomyocytes and vascular smooth muscle cells. Both in the heart and vessels, the rise of intracellular calcium is sensed by calmodulin, a protein that regulates and activates downstream kinases involved in regulating calcium signalling. Among them is the calcium calmodulin kinase family, which is involved in the regulation of cardiac functions. In this review, we present the current literature regarding the role of calcium/calmodulin pathways in the heart and vessels with the aim to summarize our mechanistic understanding of this process and to open novel avenues for research.
Identifiants
pubmed: 36555778
pii: ijms232416139
doi: 10.3390/ijms232416139
pmc: PMC9783221
pii:
doi:
Substances chimiques
Calmodulin
0
Calcium
SY7Q814VUP
Calcium-Calmodulin-Dependent Protein Kinases
EC 2.7.11.17
Calcium-Calmodulin-Dependent Protein Kinase Type 2
EC 2.7.11.17
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Diabetes. 2004 Jun;53(6):1475-81
pubmed: 15161751
Cell Calcium. 2015 Nov;58(5):489-99
pubmed: 26297240
Science. 1992 May 22;256(5060):1199-202
pubmed: 1317063
Sci Rep. 2018 Oct 4;8(1):14800
pubmed: 30287839
Heart Rhythm. 2016 Oct;13(10):2012-9
pubmed: 27374306
Circ Res. 2013 Feb 15;112(4):664-74
pubmed: 23283722
Basic Res Cardiol. 2018 Jun 15;113(4):29
pubmed: 29905892
Int J Cardiol. 2010 Feb 18;139(1):2-6
pubmed: 19523699
Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1216-25
pubmed: 26884197
Front Oncol. 2019 Apr 17;9:289
pubmed: 31058089
Stem Cells Transl Med. 2017 Sep;6(9):1759-1766
pubmed: 28688176
Genet Mol Res. 2016 Jan 22;15(1):
pubmed: 26909912
Front Physiol. 2020 Jun 18;11:539
pubmed: 32625104
Vascul Pharmacol. 2018 Mar 4;:
pubmed: 29514057
Circ Heart Fail. 2015 May;8(3):595-604
pubmed: 25740838
Trends Biochem Sci. 2016 Dec;41(12):1035-1049
pubmed: 27692849
PLoS One. 2012;7(9):e44828
pubmed: 23028635
Circ Res. 2020 Sep 11;127(7):911-927
pubmed: 32564697
Mol Ther Nucleic Acids. 2020 Sep 23;22:530-541
pubmed: 33230455
Adv Exp Med Biol. 2020;1131:649-679
pubmed: 31646529
J Muscle Res Cell Motil. 2021 Jun;42(2):291-304
pubmed: 32040690
Cell Cycle. 2011 Feb 15;10(4):631-9
pubmed: 21301225
J Physiol. 1997 May 15;501 ( Pt 1):17-31
pubmed: 9174990
iScience. 2020 Apr 24;23(4):100975
pubmed: 32222698
J Neurosci. 2017 Nov 29;37(48):11520-11522
pubmed: 29187612
Circ Res. 2017 May 26;120(11):1825-1841
pubmed: 28546359
Am J Hum Genet. 2012 Oct 5;91(4):703-12
pubmed: 23040497
Cardiovasc Res. 2007 Mar 1;73(4):641-7
pubmed: 17137569
Cold Spring Harb Perspect Biol. 2011 Nov 01;3(11):a004242
pubmed: 21875987
Int J Mol Sci. 2020 Apr 13;21(8):
pubmed: 32294899
Cell. 2007 Dec 14;131(6):1047-58
pubmed: 18083096
J Am Heart Assoc. 2012 Aug;1(4):e001081
pubmed: 23130158
Circ Res. 2006 May 26;98(10):1240-3
pubmed: 16728669
Mol Biol Evol. 1984 Nov;1(6):442-55
pubmed: 6599976
Front Pharmacol. 2014 Feb 21;5:20
pubmed: 24600393
Am J Physiol Cell Physiol. 2014 Aug 1;307(3):C221-31
pubmed: 24871857
Circulation. 2013 Mar 5;127(9):1009-17
pubmed: 23388215
PLoS One. 2015 Jun 25;10(6):e0130477
pubmed: 26110816
Sci China Life Sci. 2013 Dec;56(12):1076-85
pubmed: 24302288
Int J Cardiol. 2019 Mar 1;278:243-249
pubmed: 30538058
Exp Cell Res. 2014 May 1;323(2):352-8
pubmed: 24607448
J Biol Chem. 2013 Nov 22;288(47):33519-33529
pubmed: 24106266
Cell Mol Life Sci. 2008 Sep;65(17):2637-57
pubmed: 18463790
Am J Physiol Cell Physiol. 2005 Oct;289(4):C785-93
pubmed: 15917302
Front Pharmacol. 2014 Jan 27;5:5
pubmed: 24550830
J Biol Chem. 1996 Mar 8;271(10):5617-22
pubmed: 8621423
Front Physiol. 2019 Aug 07;10:852
pubmed: 31440163
J Biol Chem. 2000 Dec 8;275(49):38230-8
pubmed: 10988293
Biochim Biophys Acta. 1997 Oct 30;1359(1):89-96
pubmed: 9398089
Circ Res. 2003 Apr 4;92(6):659-67
pubmed: 12609973
Trends Biochem Sci. 1999 Jun;24(6):232-6
pubmed: 10366852
Atherosclerosis. 2020 Mar;297:16-24
pubmed: 32059119
Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1351-1368
pubmed: 31144989
J Cell Physiol. 2008 Jun;215(3):733-42
pubmed: 18163380
J Biol Chem. 2005 Sep 30;280(39):33101-8
pubmed: 16020540
Endocrinology. 2002 Sep;143(9):3651-7
pubmed: 12193581
Annu Rev Physiol. 2008;70:23-49
pubmed: 17988210
Curr Biol. 2019 Jan 7;29(1):81-92.e5
pubmed: 30581023
Subcell Biochem. 2007;45:169-214
pubmed: 18193638
Cells. 2022 Apr 13;11(8):
pubmed: 35456011
Physiol Rev. 2011 Jul;91(3):931-72
pubmed: 21742792
EMBO J. 1995 Aug 1;14(15):3679-86
pubmed: 7641687
Endocrinol Metab (Seoul). 2017 Sep;32(3):339-349
pubmed: 28956363
Am J Physiol Endocrinol Metab. 2014 Oct 15;307(8):E686-94
pubmed: 25159322
Cell Death Dis. 2019 Sep 11;10(9):665
pubmed: 31511499
Aging (Albany NY). 2019 Oct 25;11(20):8760-8776
pubmed: 31659144
PLoS One. 2014 Sep 25;9(9):e108201
pubmed: 25255457
Circ Res. 2004 Oct 15;95(8):798-806
pubmed: 15375008
Pharmaceuticals (Basel). 2019 Jan 07;12(1):
pubmed: 30621060
Cell Signal. 2008 Apr;20(4):613-24
pubmed: 18248957
FEBS J. 2013 Nov;280(21):5511-32
pubmed: 23663249
Autophagy. 2017 Jan 2;13(1):82-98
pubmed: 27791458
BMC Neurosci. 2014 Oct 21;15:118
pubmed: 25331941
Cell. 2014 Oct 9;159(2):281-94
pubmed: 25303525
Curr Drug Targets Inflamm Allergy. 2003 Sep;2(3):242-56
pubmed: 14561159
Cardiovasc Res. 2007 Mar 1;73(4):631-40
pubmed: 17157285
Neurochem Int. 2017 Jul;107:33-42
pubmed: 28153786
Biosci Rep. 2021 Jul 30;41(7):
pubmed: 34165505
Cell Physiol Biochem. 2020 Jan 15;54(1):27-39
pubmed: 31935048
Stroke. 2013 Sep;44(9):2559-66
pubmed: 23868268
J Cardiovasc Pharmacol. 2009 Sep;54(3):180-7
pubmed: 19333131
Cell Death Dis. 2017 Oct 5;8(10):e3076
pubmed: 28981105
J Physiol. 2016 Jun 1;594(11):2895-903
pubmed: 26824781
Heart Vessels. 2021 Feb;36(2):242-251
pubmed: 32894344
Int J Oncol. 2016 Oct;49(4):1731-6
pubmed: 27499160
Circulation. 2002 Sep 3;106(10):1288-93
pubmed: 12208807
Front Physiol. 2016 Sep 30;7:441
pubmed: 27746744
J Mol Cell Cardiol. 2011 Oct;51(4):468-73
pubmed: 21276796
Trends Neurosci. 2000 Feb;23(2):75-80
pubmed: 10652548
Science. 1998 May 22;280(5367):1258-61
pubmed: 9596578
Pharmacol Ther. 1991;50(2):255-70
pubmed: 1763137
Am J Hypertens. 1999 Oct;12(10 Pt 2):92S-95S
pubmed: 10555607
Circ Cardiovasc Genet. 2014 Aug;7(4):466-74
pubmed: 24917665
Neuroreport. 2005 Aug 22;16(12):1411-4
pubmed: 16056150
Nature. 2021 Apr;592(7855):524-533
pubmed: 33883728
Molecules. 2020 Jan 13;25(2):
pubmed: 31941153
Heart Rhythm. 2019 Jul;16(7):1080-1088
pubmed: 30654134
Clin Chim Acta. 2019 Dec;499:118-122
pubmed: 31493375
Adv Exp Med Biol. 2020;1131:395-443
pubmed: 31646519
J Mol Cell Cardiol. 2014 Aug;73:112-6
pubmed: 24530899
Endocrinology. 2010 Jun;151(6):2747-59
pubmed: 20392834
Int J Mol Sci. 2019 Nov 14;20(22):
pubmed: 31739395
Front Biosci (Landmark Ed). 2009 Jan 01;14(2):486-96
pubmed: 19273080
Genes Dev. 1994 Nov 1;8(21):2527-39
pubmed: 7958915
J Neurosci. 2004 Apr 14;24(15):3786-94
pubmed: 15084659
Circulation. 2012 Oct 23;126(17):2125-39
pubmed: 23091085
Heart Rhythm. 2015 Feb;12(2):419-22
pubmed: 25460178
J Mol Cell Cardiol. 2010 Jan;48(1):2-11
pubmed: 19744495
J Biol Chem. 2012 Jun 8;287(24):19856-69
pubmed: 22514276
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
Front Pharmacol. 2014 Jun 17;5:144
pubmed: 24987371
Tumour Biol. 2013 Oct;34(5):3147-52
pubmed: 23737288
BMC Med Genet. 2007 Sep 19;8 Suppl 1:S3
pubmed: 17903302
Signal Transduct Target Ther. 2021 Dec 16;6(1):425
pubmed: 34916492
J Vasc Res. 1995 Nov-Dec;32(6):353-70
pubmed: 8562808
Front Cardiovasc Med. 2018 Dec 06;5:175
pubmed: 30574507
J Cell Physiol. 2007 Sep;212(3):787-95
pubmed: 17477372
Mol Cell. 2017 Jun 15;66(6):780-788
pubmed: 28622523
Mol Neurobiol. 2008 Oct;38(2):153-66
pubmed: 18759010
Basic Clin Pharmacol Toxicol. 2012 Jan;110(1):42-8
pubmed: 21999706
Circ Res. 2017 May 26;120(11):1812-1824
pubmed: 28546358
Biophys J. 2015 Dec 15;109(12):2592-2601
pubmed: 26682816
Front Physiol. 2020 Jul 14;11:735
pubmed: 32760284
Mutat Res Rev Mutat Res. 2020 Oct - Dec;786:108325
pubmed: 33339582
Atherosclerosis. 2020 Aug;307:16-20
pubmed: 32702536
Neuron. 2003 Jul 17;39(2):283-97
pubmed: 12873385
Toxicology. 2018 Aug 1;406-407:70-80
pubmed: 29883672
Nat Rev Mol Cell Biol. 2018 Feb;19(2):121-135
pubmed: 28974774
Sci Rep. 2019 Aug 5;9(1):11324
pubmed: 31383913
HeartRhythm Case Rep. 2016 Mar 16;2(3):250-254
pubmed: 28491681
Biochem Biophys Res Commun. 2016 Feb 26;471(1):219-25
pubmed: 26809094
Heart Rhythm. 2011 Mar;8(3):474-7
pubmed: 20887805
Front Genet. 2019 Oct 09;10:950
pubmed: 31649728
Biochemistry. 1997 Oct 21;36(42):12823-7
pubmed: 9335539
J Biol Chem. 1997 Jun 27;272(26):16073-6
pubmed: 9195898
Sci Adv. 2020 Dec 11;6(50):
pubmed: 33310856
IUBMB Life. 2001 Apr;51(4):215-21
pubmed: 11569915
Cell Rep. 2018 Jul 3;24(1):11-19
pubmed: 29972773
Trends Cardiovasc Med. 2017 Feb;27(2):123-133
pubmed: 27576060
Circ Cardiovasc Genet. 2016 Jun;9(3):259-65
pubmed: 27114410
Int J Mol Sci. 2021 Mar 01;22(5):
pubmed: 33804544
Biosci Rep. 2017 Jul 24;37(4):
pubmed: 28739589
Pflugers Arch. 2009 Jan;457(3):657-64
pubmed: 18548270
Cardiovasc Res. 2018 Mar 15;114(4):590-600
pubmed: 29514202
Nat Commun. 2017 Jun 07;8:15742
pubmed: 28589927
Front Cardiovasc Med. 2021 May 11;8:670222
pubmed: 34046440
Circ Res. 2018 Feb 2;122(3):489-505
pubmed: 29420210
J Neurochem. 2017 Jun;141(6):808-818
pubmed: 28295333
Pharmacol Rev. 2016 Apr;68(2):476-532
pubmed: 27037223
Structure. 1995 Jan 15;3(1):7-11
pubmed: 7743133
Nature. 2002 Jan 10;415(6868):198-205
pubmed: 11805843
J Biol Chem. 2012 Sep 14;287(38):31658-65
pubmed: 22778263
Life Sci Alliance. 2020 Jul 22;3(9):
pubmed: 32699151
J Biol Chem. 2005 Aug 12;280(32):29060-6
pubmed: 15980064
Circ Res. 2006 Apr 14;98(7):868-78
pubmed: 16614312
Neurochem Int. 2017 Mar;104:6-10
pubmed: 28065796
Circ Res. 2007 Feb 16;100(3):309-27
pubmed: 17307970
Nature. 1985 May 2-8;315(6014):37-40
pubmed: 3990807
J Biol Chem. 2009 Oct 16;284(42):28554-62
pubmed: 19696021
Bioengineering (Basel). 2020 Aug 06;7(3):
pubmed: 32781528
J Neurosci. 2005 Feb 2;25(5):1281-90
pubmed: 15689566
Eur J Pharmacol. 2016 Jan 15;771:114-22
pubmed: 26694801
J Am Coll Cardiol. 2014 Jan 28;63(3):259-66
pubmed: 24076290