Profiling of Urinary Glucuronidated Bile Acids across Age Groups.
detoxification
glucuronidation
hydrophilic bile acids
uridine 5′-dipospho-glucuronosyltransferase
urinary expression
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
07 Dec 2022
07 Dec 2022
Historique:
received:
14
11
2022
revised:
01
12
2022
accepted:
06
12
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
24
12
2022
Statut:
epublish
Résumé
We investigated the age-dependent changes in urinary excretion of glucuronidated bile acids at the C-3 position. Bile acid 3-glucuronides accounted for 0.5% of urinary bile acids in neonates, and the proportion of bile acid 3-glucuronides plateaued at 1-3 years of age. The 3-glucuronides of secondary bile acids were first secreted at 3 months of age, the same time as the establishment of the gut bacterial flora in infants. A considerable portion of bile acid 3-glucuronides were present as non-amidated forms. Our results indicate dynamic hepatic enzyme activity in which the levels of uridine 5'-diphospho-glucuronosyltransferases (UGTs) differ by age group, with higher glucuronidation activity of UGTs towards nonamidated bile acids than amidated bile acids.
Identifiants
pubmed: 36557268
pii: metabo12121230
doi: 10.3390/metabo12121230
pmc: PMC9780789
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 19K08261
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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