Impact of Fecal Microbiota Transplantation on Gut Bacterial Bile Acid Metabolism in Humans.
bile acids
bile salt hydrolase (BSH)
fecal microbiome transplant (FMT)
gut microbiota
metagenomics
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
07 Dec 2022
07 Dec 2022
Historique:
received:
31
10
2022
revised:
29
11
2022
accepted:
02
12
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
27
12
2022
Statut:
epublish
Résumé
Fecal microbiota transplantation (FMT) is a promising therapeutic modality for the treatment and prevention of metabolic disease. We previously conducted a double-blind, randomized, placebo-controlled pilot trial of FMT in obese metabolically healthy patients in which we found that FMT enhanced gut bacterial bile acid metabolism and delayed the development of impaired glucose tolerance relative to the placebo control group. Therefore, we conducted a secondary analysis of fecal samples collected from these patients to assess the potential gut microbial species contributing to the effect of FMT to improve metabolic health and increase gut bacterial bile acid metabolism. Fecal samples collected at baseline and after 4 weeks of FMT or placebo treatment underwent shotgun metagenomic analysis. Ultra-high-performance liquid chromatography-mass spectrometry was used to profile fecal bile acids. FMT-enriched bacteria that have been implicated in gut bile acid metabolism included
Identifiants
pubmed: 36558359
pii: nu14245200
doi: 10.3390/nu14245200
pmc: PMC9785599
pii:
doi:
Substances chimiques
Bile Acids and Salts
0
Types de publication
Randomized Controlled Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MC_PC_12025
Pays : United Kingdom
Organisme : NCCIH NIH HHS
ID : R21 AT010956
Pays : United States
Organisme : NIH HHS
ID : R21AT010956
Pays : United States
Références
Nature. 2006 Dec 21;444(7122):1027-31
pubmed: 17183312
Yale J Biol Med. 2016 Sep 30;89(3):383-388
pubmed: 27698622
Cell. 2022 Aug 18;185(17):3263-3277.e15
pubmed: 35931082
Open Forum Infect Dis. 2019 Aug 26;6(10):ofz379
pubmed: 31660343
Front Microbiol. 2021 Oct 07;12:700718
pubmed: 34690948
Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13580-5
pubmed: 18757757
Gut. 2019 Oct;68(10):1791-1800
pubmed: 30816855
Sci Rep. 2022 Jul 16;12(1):12204
pubmed: 35842456
Nature. 2013 Jun 6;498(7452):99-103
pubmed: 23719380
J Biol Chem. 2003 Mar 14;278(11):9435-40
pubmed: 12524422
Appl Environ Microbiol. 1996 Feb;62(2):656-61
pubmed: 8593067
Am J Gastroenterol. 2013 Apr;108(4):500-8
pubmed: 23511459
Science. 1999 May 21;284(5418):1362-5
pubmed: 10334992
Gut. 2022 Jun 13;:
pubmed: 35697422
Appl Environ Microbiol. 1982 May;43(5):1057-63
pubmed: 6954878
J Lipid Res. 2006 Feb;47(2):241-59
pubmed: 16299351
mBio. 2015 Apr 21;6(2):
pubmed: 25900655
Hormones (Athens). 2021 Mar;20(1):209-211
pubmed: 33420959
Nature. 2006 Dec 21;444(7122):1022-3
pubmed: 17183309
Biotechnol Lett. 2005 Jun;27(12):817-22
pubmed: 16086241
Int J Syst Evol Microbiol. 2000 May;50 Pt 3:971-978
pubmed: 10843034
Stat Med. 2022 Aug 15;41(18):3492-3510
pubmed: 35656596
Cell Host Microbe. 2008 Apr 17;3(4):213-23
pubmed: 18407065
Nature. 2009 Jan 22;457(7228):480-4
pubmed: 19043404
Bioinformatics. 2016 Oct 1;32(19):3047-8
pubmed: 27312411
Curr Opin Gastroenterol. 2014 May;30(3):332-8
pubmed: 24625896
Biochem Biophys Res Commun. 2002 Nov 15;298(5):714-9
pubmed: 12419312
Clin Gastroenterol Hepatol. 2020 Apr;18(4):855-863.e2
pubmed: 31301451
Gut. 2016 Mar;65(3):415-425
pubmed: 26045134
Front Microbiol. 2014 Dec 10;5:678
pubmed: 25540641
Nat Commun. 2022 Jan 11;13(1):252
pubmed: 35017486
Nutrients. 2020 Jul 23;12(8):
pubmed: 32718017
J Microbiol. 2017 Nov;55(11):892-899
pubmed: 29076071
Curr Microbiol. 1995 Jul;31(1):23-7
pubmed: 7767225
Anaerobe. 2010 Apr;16(2):137-46
pubmed: 19464381
J Clin Microbiol. 2007 Aug;45(8):2747-50
pubmed: 17567792
Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G256-63
pubmed: 17412828