Enhanced Nasal Deposition and Anti-Coronavirus Effect of Favipiravir-Loaded Mucoadhesive Chitosan-Alginate Nanoparticles.
Box–Behnken design
SARS-CoV-2
alginate
antiviral
chitosan
favipiravir
intra-nasal
polymeric nanoparticles
response surface methodology
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
01 Dec 2022
01 Dec 2022
Historique:
received:
06
10
2022
revised:
23
11
2022
accepted:
25
11
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
24
12
2022
Statut:
epublish
Résumé
Favipiravir (FVR) is a repurposed antiviral drug for treating mild to moderate cases of the novel coronavirus disease 2019 (COVID-19). However, its poor solubility and permeability limit its clinical efficacy. To overcome its physicochemical and pharmacokinetic limitations, we statistically designed a mucoadhesive chitosan-alginate nanoparticles (MCS-ALG-NPs) as a new carrier for FVR using response surface methodology, which provided suitable characteristics for transmucosal delivery. The use of mucoadhesive polymers for intranasal administration promotes the residence time and contact of FVR in the mucus membrane. The optimized FVR-MCS-ALG-NPs demonstrated superior mucoadhesion, higher permeation and deposition in the nasal mucosa, and a significant increase in the inhibition of viral replication over 35-fold compared with free FVR. The overall results suggest that MCS-ALG-NPs could be used as an effective mucoadhesive carrier to enhance the activity of FVR against COVID-19.
Identifiants
pubmed: 36559173
pii: pharmaceutics14122680
doi: 10.3390/pharmaceutics14122680
pmc: PMC9782217
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : 90th Anniversary Chulalongkorn University Fund under the Ratchadaphiseksomphot Endowment Fund
ID : GCUGR1125622045D
Organisme : Thailand Science Research and Innovation Fund, Chulalongkorn University
ID : CU_FRB65_hea (56) _065_33_09
Organisme : Ratchadaphiseksomphot Endowment Fund, Chulalongkorn University
ID : RCU_H_64_035_62
Organisme : Ratchadaphiseksomphot Endowment Fund of Chulalongkorn University on Center of Excellence in Natural Products for Ageing and Chronic Diseases
ID : GCE 6503433003-1
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