Novel Therapeutic Strategies in the Topical Treatment of Atopic Dermatitis.
atopic dermatitis
pipeline
targeted therapies
topical treatment
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
10 Dec 2022
10 Dec 2022
Historique:
received:
04
11
2022
revised:
04
12
2022
accepted:
06
12
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
24
12
2022
Statut:
epublish
Résumé
Topical agents that are currently available for the treatment of atopic dermatitis may represent a valid approach in the management of mild or mild-moderate cases, whereas they are often supplemented with systemic therapies for handling more complex or unresponsive cases. The most used compounds include topical corticosteroids and calcineurin inhibitors, although their use might be burdened by side effects, poor response, and low patient compliance. Consequently, new innovative drugs with higher efficacy and safety both in the short and long term need to be integrated into clinical practice. A deeper understanding of the complex pathogenesis of the disease has led to identifying new therapeutic targets and to the development of innovative therapeutics. This narrative review aims to collect data on selected promising topical drugs that are in an advanced stage of development.
Identifiants
pubmed: 36559261
pii: pharmaceutics14122767
doi: 10.3390/pharmaceutics14122767
pmc: PMC9788207
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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