Areas of Uncertainty in SARS-CoV-2 Vaccination for Cancer Patients.

T cell assay cellular immunity humoral immunity neutralizing antibodies

Journal

Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355

Informations de publication

Date de publication:
11 Dec 2022
Historique:
received: 30 08 2022
revised: 13 11 2022
accepted: 01 12 2022
entrez: 23 12 2022
pubmed: 24 12 2022
medline: 24 12 2022
Statut: epublish

Résumé

Early in the COVID-19 pandemic, it was recognized that infection with SARS-CoV-2 is associated with increased morbidity and mortality in patients with cancer; therefore, preventive vaccination in cancer survivors is expected to be particularly impactful. Heterogeneity in how a neoplastic disease diagnosis and treatment interferes with humoral and cellular immunity, however, poses a number of challenges in vaccination strategies. Herein, the available literature on the effectiveness of COVID-19 vaccines among patients with cancer is critically appraised under the lens of anti-neoplastic treatment optimization. The objective of this review is to highlight areas of uncertainty, where more research could inform future SARS-CoV-2 immunization programs and maximize benefits in the high-risk cancer survivor population, and also minimize cancer treatment deviations from standard practices.

Identifiants

pubmed: 36560527
pii: vaccines10122117
doi: 10.3390/vaccines10122117
pmc: PMC9784623
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

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Auteurs

Anastasios Dimou (A)

Division of Medical Oncology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA.

Classifications MeSH