Thermophilic Filamentous Fungus C1-Cell-Cloned SARS-CoV-2-Spike-RBD-Subunit-Vaccine Adjuvanted with Aldydrogel
BALB/c mice
C-tag
CHO-cell
COVID-19
IgG
IgG1 and IgG2b
K18-hACE-2 mice
Myceliophthora thermophila
RBD
SARS-CoV-2
Thermothelomyces heterothallica
adjuvant
alum
aluminum-based vaccine adjuvants
antigen
baculovirus
biomanufacturing
dyadic
efficacy
glycans
glycoprotein
glycosylation
insect cells
intranasal challenge
neutralizing antibodies
pandemic
receptor binding domain
recombinant protein subunit vaccine
stability
toxicology
vaccine
variants of concern
virus
zoonotic
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
11 Dec 2022
11 Dec 2022
Historique:
received:
14
10
2022
revised:
30
11
2022
accepted:
30
11
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
24
12
2022
Statut:
epublish
Résumé
SARS-CoV-2 is evolving with increased transmission, host range, pathogenicity, and virulence. The original and mutant viruses escape host innate (Interferon) immunity and adaptive (Antibody) immunity, emphasizing unmet needs for high-yield, commercial-scale manufacturing to produce inexpensive vaccines/boosters for global/equitable distribution. We developed DYAI-100A85, a SARS-CoV-2 spike receptor binding domain (RBD) subunit antigen vaccine expressed in genetically modified thermophilic filamentous fungus,
Identifiants
pubmed: 36560529
pii: vaccines10122119
doi: 10.3390/vaccines10122119
pmc: PMC9783968
pii:
doi:
Types de publication
Journal Article
Langues
eng
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