A Vaccine Targeting Ovine Herpesvirus 2 Glycoprotein B Protects against Sheep-Associated Malignant Catarrhal Fever.
DNA immunization
malignant catarrhal fever
ovine herpesvirus-2
vaccine
viral-vector
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
15 Dec 2022
15 Dec 2022
Historique:
received:
20
11
2022
revised:
06
12
2022
accepted:
10
12
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
24
12
2022
Statut:
epublish
Résumé
Malignant catarrhal fever (MCF) is a complex and often fatal disease of ungulates. Effective vaccines are needed to avoid MCF outbreaks and mitigate losses. This study aimed to evaluate a sheep-associated MCF (SA-MCF) vaccine candidate targeting ovine herpesvirus 2 (OvHV-2) glycoprotein B (gB). Rabbits were used as a laboratory animal model to test the safety, immunogenicity, and protective efficacy of a chimeric virus consisting of a recombinant, non-pathogenic strain of alcelaphine herpesvirus-1 encoding OvHV-2 ORF8 to express gB (AlHV-1
Identifiants
pubmed: 36560568
pii: vaccines10122156
doi: 10.3390/vaccines10122156
pmc: PMC9786699
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : United States Department of Agriculture
ID : USDA-ARS CWU 2090-32000-037-00D
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