Systemic inflammatory markers in elderly patients undergoing transcatheter aortic valve replacement.
Journal
Journal of geriatric cardiology : JGC
ISSN: 1671-5411
Titre abrégé: J Geriatr Cardiol
Pays: China
ID NLM: 101237881
Informations de publication
Date de publication:
28 Nov 2022
28 Nov 2022
Historique:
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
24
12
2022
Statut:
ppublish
Résumé
Transcatheter aortic valve replacement (TAVR) provokes an early injury response, partially represented by dynamic changes in inflammatory markers. TAVR greatly benefits the elderly and we aimed to determine whether increased inflammatory markers post-TAVR in octagenerians were different than their younger counterparts and whether it was associated with adverse clinical outcomes. Patients with severe symptomatic aortic stenosis who underwent transfemoral TAVR from January 2010 to December 2021 were enrolled. Total white blood cells (WBC) count and subpopulation dynamics were evaluated. Five-hundred and seven patients were finally included in the study, 65% of these patients were 80 or more years old (54% female, median age 84 [82-87]) years, with severe symptomatic aortic stenosis. In patients aged above 80 years (patients ≥ 80), we noticed significant kinetic changes in the WBC and their differential cellular subpopulations ( This is the first description of a differential age-related inflammatory response in patients after TAVR, which shows an association between inflammatory markers post procedure and clinical outcome. Nevertheless, survival rates were similar in the elderly population and in younger patients, despite the presence of comorbid conditions.
Sections du résumé
BACKGROUND
BACKGROUND
Transcatheter aortic valve replacement (TAVR) provokes an early injury response, partially represented by dynamic changes in inflammatory markers. TAVR greatly benefits the elderly and we aimed to determine whether increased inflammatory markers post-TAVR in octagenerians were different than their younger counterparts and whether it was associated with adverse clinical outcomes.
METHODS
METHODS
Patients with severe symptomatic aortic stenosis who underwent transfemoral TAVR from January 2010 to December 2021 were enrolled. Total white blood cells (WBC) count and subpopulation dynamics were evaluated.
RESULTS
RESULTS
Five-hundred and seven patients were finally included in the study, 65% of these patients were 80 or more years old (54% female, median age 84 [82-87]) years, with severe symptomatic aortic stenosis. In patients aged above 80 years (patients ≥ 80), we noticed significant kinetic changes in the WBC and their differential cellular subpopulations (
CONCLUSION
CONCLUSIONS
This is the first description of a differential age-related inflammatory response in patients after TAVR, which shows an association between inflammatory markers post procedure and clinical outcome. Nevertheless, survival rates were similar in the elderly population and in younger patients, despite the presence of comorbid conditions.
Identifiants
pubmed: 36561055
doi: 10.11909/j.issn.1671-5411.2022.11.009
pii: jgc-19-11-811
pmc: PMC9748265
doi:
Types de publication
Journal Article
Langues
eng
Pagination
811-821Informations de copyright
© 2022 JGC All rights reserved; www.jgc301.com.
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