Arterial dissections: Common features and new perspectives.
TGF-β
aortic dissection
arterial dissection
cervical artery dissection (CeAD)
endothelial cells (ECs)
extracellular matrix
spontaneous coronary artery dissection (SCAD)
vascular smooth muscle cells (VMSCs)
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2022
2022
Historique:
received:
28
09
2022
accepted:
16
11
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
24
12
2022
Statut:
epublish
Résumé
Arterial dissections, which involve an abrupt tear in the wall of a major artery resulting in the intramural accumulation of blood, are a family of catastrophic disorders causing major, potentially fatal sequelae. Involving diverse vascular beds, including the aorta or coronary, cervical, pulmonary, and visceral arteries, each type of dissection is devastating in its own way. Traditionally they have been studied in isolation, rather than collectively, owing largely to the distinct clinical consequences of dissections in different anatomical locations - such as stroke, myocardial infarction, and renal failure. Here, we review the shared and unique features of these arteriopathies to provide a better understanding of this family of disorders. Arterial dissections occur commonly in the young to middle-aged, and often in conjunction with hypertension and/or migraine; the latter suggesting they are part of a generalized vasculopathy. Genetic studies as well as cellular and molecular investigations of arterial dissections reveal striking similarities between dissection types, particularly their pathophysiology, which includes the presence or absence of an intimal tear and vasa vasorum dysfunction as a cause of intramural hemorrhage. Pathway perturbations common to all types of dissections include disruption of TGF-β signaling, the extracellular matrix, the cytoskeleton or metabolism, as evidenced by the finding of mutations in critical genes regulating these processes, including
Identifiants
pubmed: 36561772
doi: 10.3389/fcvm.2022.1055862
pmc: PMC9763901
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1055862Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL148167
Pays : United States
Informations de copyright
Copyright © 2022 Bax, Romanov, Junday, Giannoulatou, Martinac, Kovacic, Liu, Iismaa and Graham.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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