Caffeic acid phenethyl ester: A review on its pharmacological importance, and its association with free radicals, COVID-19, and radiotherapy.
caffeic acid phenethyl ester
cancer
complementary medicine
coronavirus disease 2019
irradiation
molecular docking study
radiotherapy
therapeutic benefits
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
revised:
04
11
2022
received:
22
06
2022
accepted:
11
11
2022
pubmed:
24
12
2022
medline:
8
3
2023
entrez:
23
12
2022
Statut:
ppublish
Résumé
Caffeic acid phenethyl ester (CAPE), a main active component of propolis and a flavonoid, is one of the natural products that has attracted attention in recent years. CAPE, which has many properties such as anti-cancer, anti-inflammatory, antioxidant, antibacterial and anti-fungal, has shown many pharmacological potentials, including protective effects on multiple organs. Interestingly, molecular docking studies showed the possibility of binding of CAPE with replication enzyme. In addition, it was seen that in order to increase the binding security of the replication enzyme and CAPE, modifications can be made at three sites on the CAPE molecule, which leads to the possibility of the compound working more powerfully and usefully to prevent the proliferation of cancer cells and reduce its rate. Also, it was found that CAPE has an inhibitory effect against the main protease enzyme and may be effective in the treatment of SARS-CoV-2. This review covers in detail the importance of CAPE in alternative medicine, its pharmacological value, its potential as a cancer anti-proliferative agent, its dual role in radioprotection and radiosensitization, and its use against coronavirus disease 2019 (COVID-19).
Identifiants
pubmed: 36562210
doi: 10.1002/ptr.7707
pmc: PMC9880688
doi:
Substances chimiques
caffeic acid phenethyl ester
G960R9S5SK
Phenylethyl Alcohol
ML9LGA7468
Caffeic Acids
0
Anti-Inflammatory Agents
0
Free Radicals
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1115-1135Informations de copyright
© 2022 John Wiley & Sons Ltd.
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