New insights into apicoplast metabolism in blood-stage malaria parasites.
Journal
Current opinion in microbiology
ISSN: 1879-0364
Titre abrégé: Curr Opin Microbiol
Pays: England
ID NLM: 9815056
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
received:
03
10
2022
revised:
21
11
2022
accepted:
23
11
2022
pmc-release:
01
02
2024
pubmed:
24
12
2022
medline:
21
1
2023
entrez:
23
12
2022
Statut:
ppublish
Résumé
The apicoplast of Plasmodium falciparum is the only source of essential isoprenoid precursors and Coenzyme A (CoA) in the parasite. Isoprenoid precursor synthesis relies on the iron-sulfur cluster (FeS) cofactors produced within the apicoplast, rendering FeS synthesis an essential function of this organelle. Recent reports provide important insights into the roles of FeS cofactors and the use of isoprenoid precursors and CoA both inside and outside the apicoplast. Here, we review the recent insights into the roles of these metabolites in blood-stage malaria parasites and discuss new questions that have been raised in light of these discoveries.
Identifiants
pubmed: 36563485
pii: S1369-5274(22)00139-4
doi: 10.1016/j.mib.2022.102255
pmc: PMC9852000
mid: NIHMS1854500
pii:
doi:
Substances chimiques
Terpenes
0
Protozoan Proteins
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102255Subventions
Organisme : NIAID NIH HHS
ID : R01 AI125534
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
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