Local memory allocation recruits memory ensembles across brain regions.
CREB
auditory fear conditioning
conditioned taste aversion
cross-regional recruitment
memory allocation
memory coordination
memory ensemble
rabies
retrograde mechanism
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
15 02 2023
15 02 2023
Historique:
received:
04
04
2022
revised:
29
09
2022
accepted:
28
11
2022
pubmed:
24
12
2022
medline:
22
2
2023
entrez:
23
12
2022
Statut:
ppublish
Résumé
Memories are thought to be stored in ensembles of neurons across multiple brain regions. However, whether and how these ensembles are coordinated at the time of learning remains largely unknown. Here, we combined CREB-mediated memory allocation with transsynaptic retrograde tracing to demonstrate that the allocation of aversive memories to a group of neurons in one brain region directly affects the allocation of interconnected neurons in upstream brain regions in a behavioral- and brain region-specific manner in mice. Our analysis suggests that this cross-regional recruitment of presynaptic neurons is initiated by downstream memory neurons through a retrograde mechanism. Together with statistical modeling, our results indicate that in addition to the anterograde flow of information between brain regions, the establishment of interconnected, brain-wide memory traces relies on a retrograde mechanism that coordinates memory ensembles at the time of learning.
Identifiants
pubmed: 36563678
pii: S0896-6273(22)01072-8
doi: 10.1016/j.neuron.2022.11.018
pmc: PMC10548338
mid: NIHMS1932830
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
470-480.e5Subventions
Organisme : NIA NIH HHS
ID : R01 AG013622
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH113071
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG013622
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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