Spectrum of renal dysfunction after curative parathyroidectomy in symptomatic primary hyperparathyroidism.
PHPT
Parathyroidectomy
Primary hyperparathyroidism
Renal dysfunction
Renal tubular dysfunction
eGFR
Journal
Annales d'endocrinologie
ISSN: 2213-3941
Titre abrégé: Ann Endocrinol (Paris)
Pays: France
ID NLM: 0116744
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
21
09
2022
revised:
22
10
2022
accepted:
30
10
2022
pubmed:
24
12
2022
medline:
16
2
2023
entrez:
23
12
2022
Statut:
ppublish
Résumé
The long-term renal consequences of curative parathyroidectomy (PTX) in symptomatic primary hyperparathyroidism (sPHPT) are not well characterized. We aimed to assess renal glomerular and tubular functions in an sPHPT cohort at ≥1 year's follow-up. Retrospective-prospective study. sPHPT patients with preoperative eGFR ≥60mL/min/1.73m Forty-eight patients (31 females) with median plasma PTH 1,029 (338-1604) pg/mL and mean eGFR 109.2±26.0mL/min/1.73m Reduction in eGFR and subclinical RTD were prevalent at long-term follow-up in the present Asian-Indian cohort with cured sPHPT. Further studies are warranted to understand the clinical implications of these various renal abnormalities.
Identifiants
pubmed: 36563936
pii: S0003-4266(22)00894-0
doi: 10.1016/j.ando.2022.10.015
pii:
doi:
Substances chimiques
Bicarbonates
0
Calcium
SY7Q814VUP
Parathyroid Hormone
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
14-20Informations de copyright
Copyright © 2022 Elsevier Masson SAS. All rights reserved.