Neurovirulence, viscerotropism and immunogenicity of live attenuated yellow fever 17D vaccine virus in non-human primates.
Immunogenicity
Neurovirulence
RK 168/73
Stamaril™
Viscerotropism
Yellow fever seed virus
Journal
Vaccine
ISSN: 1873-2518
Titre abrégé: Vaccine
Pays: Netherlands
ID NLM: 8406899
Informations de publication
Date de publication:
16 01 2023
16 01 2023
Historique:
received:
11
12
2021
revised:
24
11
2022
accepted:
13
12
2022
pubmed:
24
12
2022
medline:
4
1
2023
entrez:
23
12
2022
Statut:
ppublish
Résumé
Yellow fever vaccine associated neurovirulence and viscerotropism have been reported by various countries. In this study, the neurovirulence, viscerotropism and immunogenicity of yellow fever vaccine seed lots (master and working) and final product manufactured at Serum Institute of India (SII) were evaluated in cynomolgus monkeys. WHO reference virus 168-73 and Stamaril™ as a control vaccine was used for comparison. Neurovirulence and viscerotropism scores of the seed lots and final product were lower than Stamaril™. The SII seed virus and vaccine complies to the WHO requirement for neurovirulence, viscerotropism and immunogenicity, when tested in comparison to WHO reference seed virus 168/73. All challenged animals showed 100 % seroconversion as early as day 14 and neutralizing antibody titers were sustainable at day 30 in all animals.
Identifiants
pubmed: 36564277
pii: S0264-410X(22)01543-2
doi: 10.1016/j.vaccine.2022.12.029
pii:
doi:
Substances chimiques
Yellow Fever Vaccine
0
Antigens, Viral
0
Vaccines, Attenuated
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
836-843Informations de copyright
Copyright © 2022. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: PT, MG, SM, KW, NI, SG (Sunil Gairola) and RD are employees of Serum Institute of India Private Limited, Pune, India; FK and SG (Sheila Grimes) are employees of Southern Research, USA.