Characterization of Atrial Substrate to Predict the Success of Pulmonary Vein Isolation: The Prospective, Multicenter MASH-AF II (Multipolar Atrial Substrate High Density Mapping in Atrial Fibrillation) Study.


Journal

Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524

Informations de publication

Date de publication:
03 01 2023
Historique:
pubmed: 25 12 2022
medline: 6 1 2023
entrez: 24 12 2022
Statut: ppublish

Résumé

Background Left atrial substrate may have mechanistic relevance for ablation of atrial fibrillation (AF). We sought to analyze the relationship between low-voltage zones (LVZs), transition zones, and AF recurrence in patients undergoing pulmonary vein isolation. Methods and Results We conducted a prospective multicenter study on consecutive patients undergoing pulmonary vein isolation-only approach. LVZs and transition zones (0.5-1 mV) were analyzed offline on high-density electroanatomical maps collected before pulmonary vein isolation. Overall, 262 patients (61±11 years, 31% female) with paroxysmal (130 pts) or persistent (132 pts) AF were included. After 28 months of follow-up, 73 (28%) patients experienced recurrence. An extension of more than 5% LVZ in paroxysmal AF and more than 15% in persistent AF was associated with recurrence (hazard ratio [HR], 4.4 [95% CI, 2.0-9.8],

Identifiants

pubmed: 36565183
doi: 10.1161/JAHA.122.027795
pmc: PMC9973584
doi:

Types de publication

Multicenter Study Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e027795

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Auteurs

Marco Bergonti (M)

Department of Cardiology University Hospital Antwerp Antwerp Belgium.

Francesco Raffaele Spera (FR)

Department of Cardiology University Hospital Antwerp Antwerp Belgium.

Teba Gonzalez Ferrero (TG)

Complexo Hospitalario Universitario de Santiago de Compostela (CHUS) SERGAS Santiago de Compostela Spain.

Michelle Nsahlai (M)

Department of Cardiology DeBakey Heart and Vascular Center, Houston Methodist Hospital Houston TX.

Alice Bonomi (A)

Department of Clinical Science and Community Health University of Milan at Centro Cardiologico Monzino Milan Italy.

Maxime Tijskens (M)

Department of Cardiology University Hospital Antwerp Antwerp Belgium.

Wim Boris (W)

Department of Cardiology University Hospital Antwerp Antwerp Belgium.

Johan Saenen (J)

Department of Cardiology University Hospital Antwerp Antwerp Belgium.

Wim Huybrechts (W)

Department of Cardiology University Hospital Antwerp Antwerp Belgium.

Hielko Miljoen (H)

Department of Cardiology University Hospital Antwerp Antwerp Belgium.

Jose Ramón González-Juanatey (JR)

Complexo Hospitalario Universitario de Santiago de Compostela (CHUS) SERGAS Santiago de Compostela Spain.

Jose Luis Martínez-Sande (JL)

Complexo Hospitalario Universitario de Santiago de Compostela (CHUS) SERGAS Santiago de Compostela Spain.

Lien Vandaele (L)

Department of Cardiology University Hospital Antwerp Antwerp Belgium.

Anouk Wittock (A)

Department of Anesthesiology University Hospital Antwerp Antwerp Belgium.

Hein Heidbuchel (H)

Department of Cardiology University Hospital Antwerp Antwerp Belgium.
Department GENCOR University of Antwerp Edegem Antwerp Belgium.

Miguel Valderrábano (M)

Department of Cardiology DeBakey Heart and Vascular Center, Houston Methodist Hospital Houston TX.

Moises Rodríguez-Mañero (M)

Complexo Hospitalario Universitario de Santiago de Compostela (CHUS) SERGAS Santiago de Compostela Spain.

Andrea Sarkozy (A)

Department of Cardiology University Hospital Antwerp Antwerp Belgium.
Department GENCOR University of Antwerp Edegem Antwerp Belgium.

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Classifications MeSH