High-dose chemotherapy and autologous stem cell transplantation in primary lymphomatoid granulomatosis of the central nervous system.
Lymphomatoid Granulomatosis
/ drug therapy
Methotrexate
/ therapeutic use
Thiotepa
/ therapeutic use
Cytarabine
/ therapeutic use
Carmustine
/ therapeutic use
Rituximab
/ therapeutic use
Central Nervous System Viral Diseases
/ drug therapy
Epstein-Barr Virus Infections
/ drug therapy
Humans
Antineoplastic Agents
/ therapeutic use
Male
Female
Adult
Middle Aged
Peripheral Blood Stem Cell Transplantation
Transplantation, Autologous
Antineoplastic Combined Chemotherapy Protocols
/ therapeutic use
Treatment Outcome
Autologous stem cell transplantation (ASCT)
Central nervous system (CNS)
High-dose chemotherapy (HCT)
Lymphomatoid granulomatosis (LG)
Journal
Journal of cancer research and clinical oncology
ISSN: 1432-1335
Titre abrégé: J Cancer Res Clin Oncol
Pays: Germany
ID NLM: 7902060
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
24
10
2022
accepted:
13
12
2022
medline:
24
7
2023
pubmed:
25
12
2022
entrez:
24
12
2022
Statut:
ppublish
Résumé
Primary lymphomatoid granulomatosis of the CNS (CNS-LG) is a rare lymphoid neoplasia associated Epstein-Barr Virus (EBV) and often accompanied by immunodeficiencies. No treatment standards have been defined yet. However, due to often devastating neurologic sequelae and based on similarities to diffuse large B-cell lymphoma, curative treatment requires intensive therapy protocols resembling protocols applied in CNS lymphoma. Here, the clinical courses and treatments of four primary CNS-LG patients in analogy to aggressive CNS-lymphomas including methotrexate, thiotepa, cytarabine, carmustine, and rituximab are presented. This is the first report on high-dose chemotherapy with CNS-directed drugs and autologous blood stem cell transplantation in primary CNS-LG.
Identifiants
pubmed: 36566338
doi: 10.1007/s00432-022-04531-y
pii: 10.1007/s00432-022-04531-y
pmc: PMC10356680
doi:
Substances chimiques
Methotrexate
YL5FZ2Y5U1
Thiotepa
905Z5W3GKH
Cytarabine
04079A1RDZ
Carmustine
U68WG3173Y
Rituximab
4F4X42SYQ6
Antineoplastic Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5729-5732Subventions
Organisme : Research School, Ruhr University Bochum,Germany
ID : 1224444
Informations de copyright
© 2022. The Author(s).
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