Keeping an eye on circadian time in clinical research and medicine.
chronobiology
chronomedicine
circadian
circadian medicine
daily
diurnal
human
time-of-day
translational
Journal
Clinical and translational medicine
ISSN: 2001-1326
Titre abrégé: Clin Transl Med
Pays: United States
ID NLM: 101597971
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
revised:
15
11
2022
received:
09
09
2022
accepted:
17
11
2022
entrez:
25
12
2022
pubmed:
26
12
2022
medline:
28
12
2022
Statut:
ppublish
Résumé
Daily rhythms are observed in humans and almost all other organisms. Most of these observed rhythms reflect both underlying endogenous circadian rhythms and evoked responses from behaviours such as sleep/wake, eating/fasting, rest/activity, posture changes and exercise. For many research and clinical purposes, it is important to understand the contribution of the endogenous circadian component to these observed rhythms. The goal of this manuscript is to provide guidance on best practices in measuring metrics of endogenous circadian rhythms in humans and promote the inclusion of circadian rhythms assessments in studies of health and disease. Circadian rhythms affect all aspects of physiology. By specifying minimal experimental conditions for studies, we aim to improve the quality, reliability and interpretability of research into circadian and daily (i.e., time-of-day) rhythms and facilitate the interpretation of clinical and translational findings within the context of human circadian rhythms. We describe protocols, variables and analyses commonly used for studying human daily rhythms, including how to assess the relative contributions of the endogenous circadian system and other daily patterns in behaviours or the environment. We conclude with recommendations for protocols, variables, analyses, definitions and examples of circadian terminology. Although circadian rhythms and daily effects on health outcomes can be challenging to distinguish in practice, this distinction may be important in many clinical settings. Identifying and targeting the appropriate underlying (patho)physiology is a medical goal. This review provides methods for identifying circadian effects to aid in the interpretation of published work and the inclusion of circadian factors in clinical research and practice.
Sections du résumé
BACKGROUND
Daily rhythms are observed in humans and almost all other organisms. Most of these observed rhythms reflect both underlying endogenous circadian rhythms and evoked responses from behaviours such as sleep/wake, eating/fasting, rest/activity, posture changes and exercise. For many research and clinical purposes, it is important to understand the contribution of the endogenous circadian component to these observed rhythms.
CONTENT
The goal of this manuscript is to provide guidance on best practices in measuring metrics of endogenous circadian rhythms in humans and promote the inclusion of circadian rhythms assessments in studies of health and disease. Circadian rhythms affect all aspects of physiology. By specifying minimal experimental conditions for studies, we aim to improve the quality, reliability and interpretability of research into circadian and daily (i.e., time-of-day) rhythms and facilitate the interpretation of clinical and translational findings within the context of human circadian rhythms. We describe protocols, variables and analyses commonly used for studying human daily rhythms, including how to assess the relative contributions of the endogenous circadian system and other daily patterns in behaviours or the environment. We conclude with recommendations for protocols, variables, analyses, definitions and examples of circadian terminology.
CONCLUSION
Although circadian rhythms and daily effects on health outcomes can be challenging to distinguish in practice, this distinction may be important in many clinical settings. Identifying and targeting the appropriate underlying (patho)physiology is a medical goal. This review provides methods for identifying circadian effects to aid in the interpretation of published work and the inclusion of circadian factors in clinical research and practice.
Identifiants
pubmed: 36567263
doi: 10.1002/ctm2.1131
pmc: PMC9790849
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1131Subventions
Organisme : Wellcome Trust
ID : 107849/Z/15/Z
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : U54 AG062322
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS093415
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS114526
Pays : United States
Organisme : NHLBI NIH HHS
ID : K01 HL145099
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL151368
Pays : United States
Organisme : HSRD VA
ID : I01 HX002534
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS099055
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL141706
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM139743
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL140574
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 223704/Z/21/Z
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL142648
Pays : United States
Organisme : NIMH NIH HHS
ID : R61 MH117157
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK117488
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK048520
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK102624
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK128154
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK124280
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL146245
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH121531
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL155681
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD087707
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS067139
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD103665
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK127254
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL138229
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG059867
Pays : United States
Organisme : NIGMS NIH HHS
ID : R15 GM126545
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL153969
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD107064
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS114001
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142116
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG053838
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL140580
Pays : United States
Organisme : NHLBI NIH HHS
ID : R03 HL157009
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS113065
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA025593
Pays : United States
Organisme : NINDS NIH HHS
ID : RF1 NS126547
Pays : United States
Organisme : NIDA NIH HHS
ID : R21 DA052861
Pays : United States
Organisme : NINDS NIH HHS
ID : UE5 NS128293
Pays : United States
Organisme : Wellcome Trust
ID : WT106174/Z/14/ZMA
Pays : United Kingdom
Organisme : NINR NIH HHS
ID : R01 NR018891
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG011412
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142058
Pays : United States
Informations de copyright
© 2022 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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